The role of glutathionylspermidine and trypanothione in regulation of intracellular spermidine levels during growth of Crithidia fasciculata.

A. H. Fairlamb

doi:10.1007/978-1-4684-5637-0_59

The role of glutathionylspermidine and trypanothione in regulation of intracellular spermidine levels during growth of Crithidia fasciculata.

A. H. Fairlamb

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7 Citations (Scopus)

Abstract

Trypanosomatids are unusual in that a considerable proportion of their intracellular spermidine and glutathione (GSH) is found as the conjugate Ni-glutathionylspermidine (GSH-SPD) and N1-, N8-bis-(glutathionyl)spermidine (T[SH]2)1. The latter compound is unique to the parasitic and free-living Trypanosomatidae and has been assigned the trivial name trypano-thione2.

Original language	English
Pages (from-to)	667-674
Number of pages	8
Journal	Advances in Experimental Medicine and Biology
Volume	250
DOIs	https://doi.org/10.1007/978-1-4684-5637-0_59
Publication status	Published - 1988

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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AB - Trypanosomatids are unusual in that a considerable proportion of their intracellular spermidine and glutathione (GSH) is found as the conjugate Ni-glutathionylspermidine (GSH-SPD) and N1-, N8-bis-(glutathionyl)spermidine (T[SH]2)1. The latter compound is unique to the parasitic and free-living Trypanosomatidae and has been assigned the trivial name trypano-thione2.

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SN - 0065-2598

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JF - Advances in Experimental Medicine and Biology

ER -

The role of glutathionylspermidine and trypanothione in regulation of intracellular spermidine levels during growth of Crithidia fasciculata.

Abstract

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