Projects per year
Abstract
Mammals have developed evolutionarily conserved programs of transcriptional response to hypoxia and inflammation. These stimuli commonly occur together in vivo and there is significant crosstalk between the transcription factors that are classically understood to respond to either hypoxia or inflammation. This crosstalk can be used to modulate the overall response to environmental stress. Several common disease processes are characterised by aberrant transcriptional programs in response to environmental stress. In this review, we discuss the current understanding of the role of the hypoxia-responsive (hypoxia-inducible factor) and inflammatory (nuclear factor-κB) transcription factor families and their crosstalk in rheumatoid arthritis, inflammatory bowel disease and colorectal cancer, with relevance for future therapies for the management of these conditions.
Original language | English |
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Pages (from-to) | 859-869 |
Number of pages | 11 |
Journal | International Journal of Molecular Medicine |
Volume | 35 |
Issue number | 4 |
Early online date | 27 Jan 2015 |
DOIs | |
Publication status | Published - 1 Apr 2015 |
Keywords
- Colorectal cancer
- Hypoxia
- Inflammation
- Inflammatory bowel disease
- Rheumatoid arthritis
ASJC Scopus subject areas
- Genetics
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Dive into the research topics of 'The role of hypoxia in inflammatory disease (Review)'. Together they form a unique fingerprint.Projects
- 1 Finished
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Strategic Award: Wellcome Trust Technology Platform
Blow, J. (Investigator), Lamond, A. (Investigator) & Owen-Hughes, T. (Investigator)
1/01/13 → 30/09/18
Project: Research