The role of hypoxia in inflammatory disease (Review)

John Biddlestone, Daniel Bandarra, Sonia Rocha (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    70 Citations (Scopus)

    Abstract

    Mammals have developed evolutionarily conserved programs of transcriptional response to hypoxia and inflammation. These stimuli commonly occur together in vivo and there is significant crosstalk between the transcription factors that are classically understood to respond to either hypoxia or inflammation. This crosstalk can be used to modulate the overall response to environmental stress. Several common disease processes are characterised by aberrant transcriptional programs in response to environmental stress. In this review, we discuss the current understanding of the role of the hypoxia-responsive (hypoxia-inducible factor) and inflammatory (nuclear factor-κB) transcription factor families and their crosstalk in rheumatoid arthritis, inflammatory bowel disease and colorectal cancer, with relevance for future therapies for the management of these conditions.

    Original languageEnglish
    Pages (from-to)859-869
    Number of pages11
    JournalInternational Journal of Molecular Medicine
    Volume35
    Issue number4
    Early online date27 Jan 2015
    DOIs
    Publication statusPublished - 1 Apr 2015

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    Keywords

    • Colorectal cancer
    • Hypoxia
    • Inflammation
    • Inflammatory bowel disease
    • Rheumatoid arthritis

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