The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.
Chong, J. P. J., Thömmes, P., & Blow, J. J. (1996). The role of MCM/P1 proteins in the licensing of DNA replication. Trends in Biochemical Sciences, 21(3), 102-106. https://doi.org/10.1016/S0968-0004(96)10013-X