The role of MCM/P1 proteins in the licensing of DNA replication

James P. J. Chong, Pia Thömmes, J. Julian Blow

    Research output: Contribution to journalArticlepeer-review

    158 Citations (Scopus)


    The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.
    Original languageEnglish
    Pages (from-to)102-106
    Number of pages5
    JournalTrends in Biochemical Sciences
    Issue number3
    Publication statusPublished - Mar 1996


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