The role of MCM/P1 proteins in the licensing of DNA replication

TY - JOUR

T1 - The role of MCM/P1 proteins in the licensing of DNA replication

AU - Chong, James P. J.

AU - Thömmes, Pia

AU - Blow, J. Julian

PY - 1996/3

Y1 - 1996/3

N2 - The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.

AB - The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.

U2 - 10.1016/S0968-0004(96)10013-X

DO - 10.1016/S0968-0004(96)10013-X

M3 - Article

C2 - 8882583

SN - 0968-0004

VL - 21

SP - 102

EP - 106

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 3

ER -