The Role of Notch Signalling within the Molecular Clock in the Early Development of the Skeleton

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    Abstract

    Cells possess the ability to interact with one another through complex signalling pathways. Different signals regulate how cells differentiate, undergoing modifications that ultimately allow them to adopt different cell fates and perform specific functions. The laboratory of Professor Kim Dale from the University of Dundee, Scotland, has made seminal contributions to our understanding of how the Notch signalling pathway controls the formation of tissues and organs in the earliest stages of development. Their important research has unveiled new insights into the molecular basis of Notch signalling in the context of normal development which will further our understanding of the molecular basis of developmental disorders and a multitude of diseases correlated with aberrant Notch signalling.
    Original languageEnglish
    Number of pages5
    JournalScientia
    Early online date17 Sept 2020
    DOIs
    Publication statusE-pub ahead of print - 17 Sept 2020

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