The role of O-GlcNAcylation in development

Ignacy Czajewski; Daan M. F. van Aalten

doi:10.1242/dev.201370

The role of O-GlcNAcylation in development

Ignacy Czajewski, Daan M. F. van Aalten (Lead / Corresponding author)

Gene Regulation and Expression

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Abstract

O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.

Original language	English
Article number	dev201370
Number of pages	10
Journal	Development
Volume	150
Issue number	6
Early online date	16 Mar 2023
DOIs	https://doi.org/10.1242/dev.201370
Publication status	Published - Mar 2023

Keywords

Differentiation
Glycosylation
O-GlcNAcylation
Polycomb group proteins
Stem cells

ASJC Scopus subject areas

Molecular Biology
Developmental Biology

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10.1242/dev.201370Licence: CC BY

Final Published VersionFinal published version, 597 KBLicence: CC BY

Cite this

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title = "The role of O-GlcNAcylation in development",

abstract = "O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.",

keywords = "Differentiation, Glycosylation, O-GlcNAcylation, Polycomb group proteins, Stem cells",

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note = "Funding Information: This work was funded by a Wellcome Trust Investigator Award 110061 and the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) T001682. We also thank our members of our laboratory for their critical feedback, including Laurin McDowall, Veronica Pravata, and Conor Mitchell. Copyright: {\textcopyright} 2023. Published by The Company of Biologists Ltd.",

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The role of O-GlcNAcylation in development

Abstract

Keywords

ASJC Scopus subject areas

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Molecular Mechanisms of O-GICNAC Signalling (Investigator award)

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The role of O-GlcNAcylation in development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Molecular Mechanisms of O-GICNAC Signalling (Investigator award)

Cite this