The role of O-GlcNAcylation in development

Ignacy Czajewski, Daan M. F. van Aalten (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

7 Downloads (Pure)


O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.

Original languageEnglish
Article numberdev201370
Number of pages10
Issue number6
Early online date16 Mar 2023
Publication statusPublished - Mar 2023


  • Differentiation
  • Glycosylation
  • O-GlcNAcylation
  • Polycomb group proteins
  • Stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


Dive into the research topics of 'The role of O-GlcNAcylation in development'. Together they form a unique fingerprint.

Cite this