The role of protein phosphorylation in human health and disease: Delivered on June 30th 2001 at the FEBS meeting in Lisbon

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    Abstract

    The reversible phosphorylation of proteins regulates almost all aspects of cell life, while abnormal phosphorylation is a cause or consequence of many diseases. Mutations in particular protein kinases and phosphatases gives rise to a number of disorders and many naturally occurring toxins and pathogens exert their effects by altering the phosphorylation states of intracellular proteins. In this lecture, I present an overview of the progress that is being made in developing specific inhibitors of protein kinases for the treatment of cancer and chronic inflammatory diseases and describe how recent advances in our understanding of the specificity and regulation of one particular protein kinase (GSK3) may facilitate the development of drugs to treat diabetes that would not have the potential to be oncogenic. I also discuss the exploitation of specific protein kinase inhibitors for the study of cell signalling and make recommendations for their effective use in cell-based assays.

    Original languageEnglish
    Pages (from-to)5001-5010
    Number of pages10
    JournalEuropean Journal of Biochemistry
    Volume268
    Issue number19
    DOIs
    Publication statusPublished - 22 Oct 2001

    Keywords

    • Cancer
    • Diabetes
    • Drugs
    • GSK3
    • Inflammation
    • Phosphorylation
    • Protein kinase
    • Signal transduction
    • Wnt

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