The role of sampling in clinical trial design

Merton Krause; Wolfgang Lutz; Jan R Boehnke

doi:10.1080/10503307.2010.549520

The role of sampling in clinical trial design

Merton Krause, Wolfgang Lutz, Jan R Boehnke

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A treatment's recovery rate depends upon the percentage of clients who received the treatment and recovered. This rate is not logically interpretable as the personal probability of recovery of any individual client assigned to this treatment unless the rate is 0% or 100%. So clinical trials need to be designed to help us learn how to distinguish before treatment the sorts of clients who recover in response to each available form of treatment from those who do not. This requires our developing sufficiently comprehensive sampling of clients and client covariates as part of the design of clinical trials, which would be more likely and efficiently achieved were there centralized programmatic planning and coordination of the development of these aspects of clinical trial design.

Original language	English
Pages (from-to)	243-51
Number of pages	9
Journal	Psychotherapy Research
Volume	21
Issue number	3
Early online date	23 Feb 2011
DOIs	https://doi.org/10.1080/10503307.2010.549520
Publication status	Published - May 2011

Keywords

Data Interpretation, Statistical
Humans
Likelihood Functions
Mass Screening
Probability
Psychotherapy
Randomized Controlled Trials as Topic
Research Design
Sampling Studies
Treatment Outcome
Journal Article

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10.1080/10503307.2010.549520

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Boehnke, J. (Speaker)
6 Jul 2022
Activity: Talk or presentation types › Oral presentation
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Boehnke, J. (Chair)
9 Jul 2022
Activity: Talk or presentation types › Oral presentation

Cite this

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title = "The role of sampling in clinical trial design",

abstract = "A treatment's recovery rate depends upon the percentage of clients who received the treatment and recovered. This rate is not logically interpretable as the personal probability of recovery of any individual client assigned to this treatment unless the rate is 0% or 100%. So clinical trials need to be designed to help us learn how to distinguish before treatment the sorts of clients who recover in response to each available form of treatment from those who do not. This requires our developing sufficiently comprehensive sampling of clients and client covariates as part of the design of clinical trials, which would be more likely and efficiently achieved were there centralized programmatic planning and coordination of the development of these aspects of clinical trial design.",

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KW - Data Interpretation, Statistical

KW - Humans

KW - Likelihood Functions

KW - Mass Screening

KW - Probability

KW - Psychotherapy

KW - Randomized Controlled Trials as Topic

KW - Research Design

KW - Sampling Studies

KW - Treatment Outcome

KW - Journal Article

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DO - 10.1080/10503307.2010.549520

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SN - 1050-3307

VL - 21

SP - 243

EP - 251

JO - Psychotherapy Research

JF - Psychotherapy Research

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ER -

The role of sampling in clinical trial design

Abstract

Keywords

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Selecting predictors in regression models: What can regularized regression models do for process-outcome research?

Challenges and Opportunities When Measuring Meaningful Therapeutic Change

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