Abstract
The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological role of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.
Original language | English |
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Pages (from-to) | 383-392 |
Number of pages | 10 |
Journal | Anti-Cancer Drug Design |
Volume | 14 |
Issue number | 5 |
Publication status | Published - 1999 |
Keywords
- 5-fluorouracil
- Angiogenesis
- Anti-cancer drugs
- PD-ECGF
- Thymidine phosphorylase
- TP inhibitors
ASJC Scopus subject areas
- Biochemistry
- General Biochemistry,Genetics and Molecular Biology
- Oncology
- Pharmacology
- Drug Discovery
- Organic Chemistry