The role of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: A chemical perspective

Christian Cole, Alison J. Foster, Sally Freeman, Mohammed Jaffar, Paul E. Murray, Ian J. Stratford

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological role of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.

Original languageEnglish
Pages (from-to)383-392
Number of pages10
JournalAnti-Cancer Drug Design
Volume14
Issue number5
Publication statusPublished - 1999

Keywords

  • 5-fluorouracil
  • Angiogenesis
  • Anti-cancer drugs
  • PD-ECGF
  • Thymidine phosphorylase
  • TP inhibitors

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