The search for physiological substrates of MAP and SAP kinases in mammalian cells

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    Abstract

    Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family members. This review discusses recent progress in understanding some of the functions of these enzymes that has been made possible by the introduction of some novel approaches, particularly the use of two specific inhibitors.

    Original languageEnglish
    Pages (from-to)353-361
    Number of pages9
    JournalTrends in Cell Biology
    Volume7
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 1997

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