The search for physiological substrates of MAP and SAP kinases in mammalian cells

Philip Cohen

doi:10.1016/S0962-8924(97)01105-7

The search for physiological substrates of MAP and SAP kinases in mammalian cells

Philip Cohen

Research output: Contribution to journal › Review article › peer-review

520 Citations (Scopus)

Abstract

Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family members. This review discusses recent progress in understanding some of the functions of these enzymes that has been made possible by the introduction of some novel approaches, particularly the use of two specific inhibitors.

Original language	English
Pages (from-to)	353-361
Number of pages	9
Journal	Trends in Cell Biology
Volume	7
Issue number	9
DOIs	https://doi.org/10.1016/S0962-8924(97)01105-7
Publication status	Published - 1 Sept 1997

ASJC Scopus subject areas

Cell Biology

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The search for physiological substrates of MAP and SAP kinases in mammalian cells

Abstract

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