The search for predictive metabolic biomarkers for incident T2DM

Ewan Pearson; Jerzy Adamski

doi:10.1038/s41574-018-0045-x

The search for predictive metabolic biomarkers for incident T2DM

Ewan Pearson, Jerzy Adamski (Lead / Corresponding author)

Population Health and Genomics

Research output: Contribution to journal › Comment/debate › peer-review

2 Citations (Scopus)

Abstract

A recent metabolomics study of plasma samples from normoglycaemic individuals has identified new predictive biomarkers for type 2 diabetes mellitus. The biomarkers described by the authors demonstrate a potential causal connection between changes in glycine and phenylalanine and incident diabetes mellitus.

Original language	English
Pages (from-to)	444-446
Number of pages	3
Journal	Nature Reviews Endocrinology
Volume	14
Issue number	8
DOIs	https://doi.org/10.1038/s41574-018-0045-x
Publication status	Published - 18 Jun 2018

Keywords

Metabolomics
Public health
Risk factors
Type 2 diabetes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41574-018-0045-x

1 Finished
1 Active

DIRECT: Diabetes Research on Patient Stratification (joint with 25 other partners)
Colhoun, H., Houston, G., Morris, A., Palmer, C. & Pearson, E.
COMMISSION OF THE EUROPEAN COMMUNITIES
1/02/12 → 30/06/23
Project: Research
Stratified Medicine in Type 2 Diabetes: Insights from the Study of Drug Response (New Investigator Award)
Pearson, E.
Wellcome Trust
16/02/15 → 15/08/21
Project: Research

Cite this

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title = "The search for predictive metabolic biomarkers for incident T2DM",

abstract = "A recent metabolomics study of plasma samples from normoglycaemic individuals has identified new predictive biomarkers for type 2 diabetes mellitus. The biomarkers described by the authors demonstrate a potential causal connection between changes in glycine and phenylalanine and incident diabetes mellitus.",

keywords = "Metabolomics, Public health, Risk factors, Type 2 diabetes",

author = "Ewan Pearson and Jerzy Adamski",

note = "The authors{\textquoteright} work was supported, in part, by Innovative Medicines Initiative Joint Undertaking under grant agreement number 115317 (DIRECT), European Institute of Innovation & Technology (EIT) Health Innovation Projects grant DeTecT2D (18428) and the German Federal Ministry of Education and Research (BMBF) to the German Center Diabetes Research (DZD e.V.) grant that was awarded to J.A. E.R.P. holds a Wellcome trust New investigator award (102820/Z/13/Z).",

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AU - Pearson, Ewan

AU - Adamski, Jerzy

N1 - The authors’ work was supported, in part, by Innovative Medicines Initiative Joint Undertaking under grant agreement number 115317 (DIRECT), European Institute of Innovation & Technology (EIT) Health Innovation Projects grant DeTecT2D (18428) and the German Federal Ministry of Education and Research (BMBF) to the German Center Diabetes Research (DZD e.V.) grant that was awarded to J.A. E.R.P. holds a Wellcome trust New investigator award (102820/Z/13/Z).

PY - 2018/6/18

Y1 - 2018/6/18

N2 - A recent metabolomics study of plasma samples from normoglycaemic individuals has identified new predictive biomarkers for type 2 diabetes mellitus. The biomarkers described by the authors demonstrate a potential causal connection between changes in glycine and phenylalanine and incident diabetes mellitus.

AB - A recent metabolomics study of plasma samples from normoglycaemic individuals has identified new predictive biomarkers for type 2 diabetes mellitus. The biomarkers described by the authors demonstrate a potential causal connection between changes in glycine and phenylalanine and incident diabetes mellitus.

KW - Metabolomics

KW - Public health

KW - Risk factors

KW - Type 2 diabetes

U2 - 10.1038/s41574-018-0045-x

DO - 10.1038/s41574-018-0045-x

M3 - Comment/debate

C2 - 29915218

AN - SCOPUS:85048676759

SN - 1759-5029

VL - 14

SP - 444

EP - 446

JO - Nature Reviews Endocrinology

JF - Nature Reviews Endocrinology

IS - 8

ER -

The search for predictive metabolic biomarkers for incident T2DM

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Projects

DIRECT: Diabetes Research on Patient Stratification (joint with 25 other partners)

Stratified Medicine in Type 2 Diabetes: Insights from the Study of Drug Response (New Investigator Award)

Cite this