The segmentation clock mechanism moves up a notch

Sarah Gibb; Miguel Maroto; J. Kim Dale

doi:10.1016/j.tcb.2010.07.001

The segmentation clock mechanism moves up a notch

Sarah Gibb, Miguel Maroto, J. Kim Dale

Research output: Contribution to journal › Review article › peer-review

69 Citations (Scopus)

Abstract

The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation. Three signalling pathways have been proposed to underlie the molecular mechanism of the oscillator, namely the Notch, Wnt and Fgf pathways. Characterizing the roles and hierarchy of these three pathways in the oscillator mechanism is currently the focus of intense research. Recent publications report the first identification of a molecular mechanism involved in the regulation of the pace of this oscillator. We review these and other recent findings regarding the interaction between the three pathways in the oscillator mechanism that have significantly expanded our understanding of the segmentation clock.

Original language	English
Pages (from-to)	593-600
Number of pages	8
Journal	Trends in Cell Biology
Volume	20
Issue number	10
DOIs	https://doi.org/10.1016/j.tcb.2010.07.001
Publication status	Published - Oct 2010

Keywords

Cyclic gene expression
Somite boundary formation
Presomitic mesoderm
Signaling pathway
Lunatic fringe
Vertebrate segmentation
Somitogenesis oscillator
Zebrafish somitogenesis
Paraxial mesoderm
Chick embryo

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10.1016/j.tcb.2010.07.001

Aref#d: 21932. The Interplay of Wnt and Notch Signalling in the Segmentation Clock Mechanism
Dale, K. (Investigator)
23/11/09 → 22/11/13
Project: Research

Cite this

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title = "The segmentation clock mechanism moves up a notch",

abstract = "The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation. Three signalling pathways have been proposed to underlie the molecular mechanism of the oscillator, namely the Notch, Wnt and Fgf pathways. Characterizing the roles and hierarchy of these three pathways in the oscillator mechanism is currently the focus of intense research. Recent publications report the first identification of a molecular mechanism involved in the regulation of the pace of this oscillator. We review these and other recent findings regarding the interaction between the three pathways in the oscillator mechanism that have significantly expanded our understanding of the segmentation clock.",

keywords = "Cyclic gene expression, Somite boundary formation, Presomitic mesoderm, Signaling pathway, Lunatic fringe, Vertebrate segmentation, Somitogenesis oscillator, Zebrafish somitogenesis, Paraxial mesoderm, Chick embryo",

author = "Sarah Gibb and Miguel Maroto and Dale, {J. Kim}",

year = "2010",

month = oct,

doi = "10.1016/j.tcb.2010.07.001",

language = "English",

volume = "20",

pages = "593--600",

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T1 - The segmentation clock mechanism moves up a notch

AU - Gibb, Sarah

AU - Maroto, Miguel

AU - Dale, J. Kim

PY - 2010/10

Y1 - 2010/10

N2 - The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation. Three signalling pathways have been proposed to underlie the molecular mechanism of the oscillator, namely the Notch, Wnt and Fgf pathways. Characterizing the roles and hierarchy of these three pathways in the oscillator mechanism is currently the focus of intense research. Recent publications report the first identification of a molecular mechanism involved in the regulation of the pace of this oscillator. We review these and other recent findings regarding the interaction between the three pathways in the oscillator mechanism that have significantly expanded our understanding of the segmentation clock.

AB - The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation. Three signalling pathways have been proposed to underlie the molecular mechanism of the oscillator, namely the Notch, Wnt and Fgf pathways. Characterizing the roles and hierarchy of these three pathways in the oscillator mechanism is currently the focus of intense research. Recent publications report the first identification of a molecular mechanism involved in the regulation of the pace of this oscillator. We review these and other recent findings regarding the interaction between the three pathways in the oscillator mechanism that have significantly expanded our understanding of the segmentation clock.

KW - Cyclic gene expression

KW - Somite boundary formation

KW - Presomitic mesoderm

KW - Signaling pathway

KW - Lunatic fringe

KW - Vertebrate segmentation

KW - Somitogenesis oscillator

KW - Zebrafish somitogenesis

KW - Paraxial mesoderm

KW - Chick embryo

U2 - 10.1016/j.tcb.2010.07.001

DO - 10.1016/j.tcb.2010.07.001

M3 - Review article

C2 - 20724159

SN - 0962-8924

VL - 20

SP - 593

EP - 600

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 10

ER -

The segmentation clock mechanism moves up a notch

Abstract

Keywords

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Aref#d: 21932. The Interplay of Wnt and Notch Signalling in the Segmentation Clock Mechanism

Cite this