The segmentation clock mechanism moves up a notch

Sarah Gibb, Miguel Maroto, J. Kim Dale

    Research output: Contribution to journalReview article

    54 Citations (Scopus)

    Abstract

    The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation. Three signalling pathways have been proposed to underlie the molecular mechanism of the oscillator, namely the Notch, Wnt and Fgf pathways. Characterizing the roles and hierarchy of these three pathways in the oscillator mechanism is currently the focus of intense research. Recent publications report the first identification of a molecular mechanism involved in the regulation of the pace of this oscillator. We review these and other recent findings regarding the interaction between the three pathways in the oscillator mechanism that have significantly expanded our understanding of the segmentation clock.

    Original languageEnglish
    Pages (from-to)593-600
    Number of pages8
    JournalTrends in Cell Biology
    Volume20
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

    Keywords

    • Cyclic gene expression
    • Somite boundary formation
    • Presomitic mesoderm
    • Signaling pathway
    • Lunatic fringe
    • Vertebrate segmentation
    • Somitogenesis oscillator
    • Zebrafish somitogenesis
    • Paraxial mesoderm
    • Chick embryo

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