TY - JOUR
T1 - The SMC family
T2 - from chromosome condensation to dosage compensation
AU - Hirano, Tatsuya
AU - Mitchison, Timothy J
AU - Swedlow, Jason R
N1 - Funding Information:
We thank A Strunnikov and D Koshiand for sharing datap rior to publication. The work in the authors’ laboratory was supported by Tobacco-Related Disease Research Program of the University of California to TJ Mitchison. T Hirano is a Leukemia Society of America Special Fellow; JR Swedlow is a Fellow of the Damon Runyon-Walter Winchell Cancer Research Fund.
PY - 1995
Y1 - 1995
N2 - Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.
AB - Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.
UR - http://www.scopus.com/inward/record.url?scp=0029038932&partnerID=8YFLogxK
U2 - 10.1016/0955-0674(95)80087-5
DO - 10.1016/0955-0674(95)80087-5
M3 - Article
C2 - 7662362
AN - SCOPUS:0029038932
SN - 0955-0674
VL - 7
SP - 329
EP - 336
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -