The SMC family: from chromosome condensation to dosage compensation

Tatsuya Hirano, Timothy J Mitchison, Jason R Swedlow

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume7
Issue number3
DOIs
Publication statusPublished - 1995

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