The SMC family: from chromosome condensation to dosage compensation

Tatsuya Hirano; Timothy J Mitchison; Jason R Swedlow

doi:10.1016/0955-0674(95)80087-5

The SMC family: from chromosome condensation to dosage compensation

Tatsuya Hirano
, Timothy J Mitchison
, Jason R Swedlow

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.

Original language	English
Pages (from-to)	329-336
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0955-0674(95)80087-5
Publication status	Published - 1995

ASJC Scopus subject areas

Cell Biology

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title = "The SMC family: from chromosome condensation to dosage compensation",

abstract = "Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.",

author = "Tatsuya Hirano and Mitchison, \{Timothy J\} and Swedlow, \{Jason R\}",

note = "Funding Information: We thank A Strunnikov and D Koshiand for sharing datap rior to publication. The work in the authors{\textquoteright} laboratory was supported by Tobacco-Related Disease Research Program of the University of California to TJ Mitchison. T Hirano is a Leukemia Society of America Special Fellow; JR Swedlow is a Fellow of the Damon Runyon-Walter Winchell Cancer Research Fund.",

year = "1995",

doi = "10.1016/0955-0674(95)80087-5",

language = "English",

volume = "7",

pages = "329--336",

journal = "Current Opinion in Cell Biology",

issn = "0955-0674",

publisher = "Elsevier",

number = "3",

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TY - JOUR

T1 - The SMC family

T2 - from chromosome condensation to dosage compensation

AU - Hirano, Tatsuya

AU - Mitchison, Timothy J

AU - Swedlow, Jason R

N1 - Funding Information: We thank A Strunnikov and D Koshiand for sharing datap rior to publication. The work in the authors’ laboratory was supported by Tobacco-Related Disease Research Program of the University of California to TJ Mitchison. T Hirano is a Leukemia Society of America Special Fellow; JR Swedlow is a Fellow of the Damon Runyon-Walter Winchell Cancer Research Fund.

PY - 1995

Y1 - 1995

N2 - Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.

AB - Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.

UR - https://www.scopus.com/pages/publications/0029038932

U2 - 10.1016/0955-0674(95)80087-5

DO - 10.1016/0955-0674(95)80087-5

M3 - Article

C2 - 7662362

AN - SCOPUS:0029038932

SN - 0955-0674

VL - 7

SP - 329

EP - 336

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 3

ER -

The SMC family: from chromosome condensation to dosage compensation

Abstract

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