The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteria

Gwen Kennedy, Neil C. Abbot, Vance Spence, Christine Underwood, Jill J. F. Belch

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Purpose
    The Centers for Disease Control (CDC)-1994 definition of chronic fatigue syndrome (CFS) is very broad, and there have been suggestions that it lacks specificity. To test this, we have compared three groups of patients, all of whom fulfill the criteria but self-report different etiologies.
    Methods
    Patients with self-reported symptoms which developed sporadically (sCFS, n = 48); after Gulf War service (GW, n = 24); and following exposure to organophosphate insecticides (OP, n = 25) underwent a clinical examination, completed the MOS SF-36 quality of life and Hospital Anxiety and Depression scales, and were assessed for major and minor criteria for CDC-1994 CFS.
    Results
    Significant differences in simple clinical measures and outcome measures were observed between groups. The GW group had significantly more severe physical symptoms—fatigue, muscle and multi-joint pain—than OP or sCFS, and the sCFS group was significantly less impaired than the other two groups in terms of role emotional and mental health. In all three groups, a majority of patients exhibited muscle weakness in the lower limbs, and significant numbers of patients had absent or abnormal reflexes.
    Conclusions
    Differences in simple, easily performed clinical outcome measurements can be observed between groups of patients, all of whom fulfill the CDC-1994 criteria for CFS. It is likely that their response to treatment may also vary. The specificity of the CFS case definition should be improved to define more homogeneous groups of patients for the purposes of treatment and research.
    Original languageEnglish
    Pages (from-to)95-100
    Number of pages6
    JournalAnnals of Epidemiology
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - Feb 2004

    Fingerprint

    Chronic Fatigue Syndrome
    Centers for Disease Control and Prevention (U.S.)
    Health Status
    Abnormal Reflexes
    Gulf War
    Organophosphates
    Muscle Weakness
    Insecticides
    Self Report
    Lower Extremity
    Mental Health
    Anxiety
    Joints
    Quality of Life
    Outcome Assessment (Health Care)
    Depression
    Muscles
    Therapeutics
    Research

    Cite this

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    title = "The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteria",
    abstract = "PurposeThe Centers for Disease Control (CDC)-1994 definition of chronic fatigue syndrome (CFS) is very broad, and there have been suggestions that it lacks specificity. To test this, we have compared three groups of patients, all of whom fulfill the criteria but self-report different etiologies.MethodsPatients with self-reported symptoms which developed sporadically (sCFS, n = 48); after Gulf War service (GW, n = 24); and following exposure to organophosphate insecticides (OP, n = 25) underwent a clinical examination, completed the MOS SF-36 quality of life and Hospital Anxiety and Depression scales, and were assessed for major and minor criteria for CDC-1994 CFS.ResultsSignificant differences in simple clinical measures and outcome measures were observed between groups. The GW group had significantly more severe physical symptoms—fatigue, muscle and multi-joint pain—than OP or sCFS, and the sCFS group was significantly less impaired than the other two groups in terms of role emotional and mental health. In all three groups, a majority of patients exhibited muscle weakness in the lower limbs, and significant numbers of patients had absent or abnormal reflexes.ConclusionsDifferences in simple, easily performed clinical outcome measurements can be observed between groups of patients, all of whom fulfill the CDC-1994 criteria for CFS. It is likely that their response to treatment may also vary. The specificity of the CFS case definition should be improved to define more homogeneous groups of patients for the purposes of treatment and research.",
    author = "Gwen Kennedy and Abbot, {Neil C.} and Vance Spence and Christine Underwood and Belch, {Jill J. F.}",
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    The specificity of the CDC-1994 criteria for chronic fatigue syndrome : comparison of health status in three groups of patients who fulfill the criteria. / Kennedy, Gwen; Abbot, Neil C.; Spence, Vance; Underwood, Christine; Belch, Jill J. F.

    In: Annals of Epidemiology, Vol. 14, No. 2, 02.2004, p. 95-100.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The specificity of the CDC-1994 criteria for chronic fatigue syndrome

    T2 - comparison of health status in three groups of patients who fulfill the criteria

    AU - Kennedy, Gwen

    AU - Abbot, Neil C.

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    AU - Underwood, Christine

    AU - Belch, Jill J. F.

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    N2 - PurposeThe Centers for Disease Control (CDC)-1994 definition of chronic fatigue syndrome (CFS) is very broad, and there have been suggestions that it lacks specificity. To test this, we have compared three groups of patients, all of whom fulfill the criteria but self-report different etiologies.MethodsPatients with self-reported symptoms which developed sporadically (sCFS, n = 48); after Gulf War service (GW, n = 24); and following exposure to organophosphate insecticides (OP, n = 25) underwent a clinical examination, completed the MOS SF-36 quality of life and Hospital Anxiety and Depression scales, and were assessed for major and minor criteria for CDC-1994 CFS.ResultsSignificant differences in simple clinical measures and outcome measures were observed between groups. The GW group had significantly more severe physical symptoms—fatigue, muscle and multi-joint pain—than OP or sCFS, and the sCFS group was significantly less impaired than the other two groups in terms of role emotional and mental health. In all three groups, a majority of patients exhibited muscle weakness in the lower limbs, and significant numbers of patients had absent or abnormal reflexes.ConclusionsDifferences in simple, easily performed clinical outcome measurements can be observed between groups of patients, all of whom fulfill the CDC-1994 criteria for CFS. It is likely that their response to treatment may also vary. The specificity of the CFS case definition should be improved to define more homogeneous groups of patients for the purposes of treatment and research.

    AB - PurposeThe Centers for Disease Control (CDC)-1994 definition of chronic fatigue syndrome (CFS) is very broad, and there have been suggestions that it lacks specificity. To test this, we have compared three groups of patients, all of whom fulfill the criteria but self-report different etiologies.MethodsPatients with self-reported symptoms which developed sporadically (sCFS, n = 48); after Gulf War service (GW, n = 24); and following exposure to organophosphate insecticides (OP, n = 25) underwent a clinical examination, completed the MOS SF-36 quality of life and Hospital Anxiety and Depression scales, and were assessed for major and minor criteria for CDC-1994 CFS.ResultsSignificant differences in simple clinical measures and outcome measures were observed between groups. The GW group had significantly more severe physical symptoms—fatigue, muscle and multi-joint pain—than OP or sCFS, and the sCFS group was significantly less impaired than the other two groups in terms of role emotional and mental health. In all three groups, a majority of patients exhibited muscle weakness in the lower limbs, and significant numbers of patients had absent or abnormal reflexes.ConclusionsDifferences in simple, easily performed clinical outcome measurements can be observed between groups of patients, all of whom fulfill the CDC-1994 criteria for CFS. It is likely that their response to treatment may also vary. The specificity of the CFS case definition should be improved to define more homogeneous groups of patients for the purposes of treatment and research.

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