TY - JOUR
T1 - The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding
AU - Emsley, Paul
AU - Fotinou, Constantina
AU - Black, Isobel
AU - Fairweather, Neil F.
AU - Charles, Ian G.
AU - Watts, Colin
AU - Hewitt, Eric
AU - Isaacs, Neil W.
PY - 2000/3/24
Y1 - 2000/3/24
N2 - The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(c) and of H(c) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.
AB - The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(c) and of H(c) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.
UR - http://www.scopus.com/inward/record.url?scp=0034708794&partnerID=8YFLogxK
U2 - 10.1074/jbc.275.12.8889
DO - 10.1074/jbc.275.12.8889
M3 - Article
C2 - 10722735
AN - SCOPUS:0034708794
SN - 0021-9258
VL - 275
SP - 8889
EP - 8894
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 12
ER -