The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein kinase B and ribosomal S6 kinase 1

Virginie Lafont (Lead / Corresponding author), Emmanuelle Astoul, Arian Laurence, Janny Liautard, Doreen Cantrell

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    The present study has explored T cell antigen receptor-regulated serine kinases in human T cells. The results identify two phosphatidylinositol 3-kinase (PI3K)-controlled serine kinases operating downstream of the T cell receptor (TCR) in primary T cells: (i) protein kinase B whose activation regulates the phosphorylation of glycogen synthase kinase 3 and (ii) ribosomal S6 kinase 1, a kinase with a critical role in the regulation of protein synthesis and cell growth. T cells express two isoforms of S6k1: a 70 kDa cytoplasmic kinase and an 85 kDa isoform that has a classic nuclear localisation. TCR ligation triggers a parallel engagement of both the 70 and 85 kDa isoforms of S6k1 in a response that requires PI3K function. (C) 2000 Federation of European Biochemical Societies.

    Original languageEnglish
    Pages (from-to)38-42
    Number of pages5
    JournalFEBS Letters
    Volume486
    Issue number1
    DOIs
    Publication statusPublished - 1 Dec 2000

    Keywords

    • Glycogen synthase kinase-3
    • Phosphatidylinositol 3-kinase
    • Protein kinase B
    • Ribosomal S6 kinase 1
    • T cell receptor

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