The Tat protein export pathway

Ben C Berks, Frank Sargent, Tracy Palmer

    Research output: Contribution to journalReview articlepeer-review

    477 Citations (Scopus)


    The Tat (twin-arginine translocation) system is a bacterial protein export pathway with the remarkable ability to transport folded proteins across the cytoplasmic membrane. Preproteins are directed to the Tat pathway by signal peptides that bear a characteristic sequence motif, which includes consecutive arginine residues. Here, we review recent progress on the characterization of the Tat system and critically discuss the structure and operation of this major new bacterial protein export pathway.

    Original languageEnglish
    Pages (from-to)260-274
    Number of pages15
    JournalMolecular Microbiology
    Issue number2
    Publication statusPublished - Jan 2000


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