The Tat protein translocation pathway and its role in microbial physiology

Ben C. Berks, Tracy Palmer, Frank Sargent

    Research output: Contribution to journalArticlepeer-review

    209 Citations (Scopus)


    The Tat (twin arginine translocation) protein transport system functions to export folded protein substrates across the bacterial cytoplasmic membrane and to insert certain integral membrane proteins into that membrane. It is entirely distinct from the Sec pathway. Here, we describe our current knowledge of the molecular features of the Tat transport system. In addition, we discuss the roles that the Tat pathway plays in the bacterial cell, paying particular attention to the involvement of the Tat pathway in the biogenesis of cofactor-containing proteins, in cell wall biosynthesis and in bacterial pathogenicity.
    Original languageEnglish
    Pages (from-to)187-254
    Number of pages68
    JournalAdvances in Microbial Physiology
    Publication statusPublished - 2003


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