The Tat protein translocation pathway and its role in microbial physiology

TY - JOUR

T1 - The Tat protein translocation pathway and its role in microbial physiology

AU - Berks, Ben C.

AU - Palmer, Tracy

AU - Sargent, Frank

PY - 2003

Y1 - 2003

N2 - The Tat (twin arginine translocation) protein transport system functions to export folded protein substrates across the bacterial cytoplasmic membrane and to insert certain integral membrane proteins into that membrane. It is entirely distinct from the Sec pathway. Here, we describe our current knowledge of the molecular features of the Tat transport system. In addition, we discuss the roles that the Tat pathway plays in the bacterial cell, paying particular attention to the involvement of the Tat pathway in the biogenesis of cofactor-containing proteins, in cell wall biosynthesis and in bacterial pathogenicity.

AB - The Tat (twin arginine translocation) protein transport system functions to export folded protein substrates across the bacterial cytoplasmic membrane and to insert certain integral membrane proteins into that membrane. It is entirely distinct from the Sec pathway. Here, we describe our current knowledge of the molecular features of the Tat transport system. In addition, we discuss the roles that the Tat pathway plays in the bacterial cell, paying particular attention to the involvement of the Tat pathway in the biogenesis of cofactor-containing proteins, in cell wall biosynthesis and in bacterial pathogenicity.

U2 - 10.1016/S0065-2911(03)47004-5

DO - 10.1016/S0065-2911(03)47004-5

M3 - Article

SN - 0065-2911

VL - 47

SP - 187

EP - 254

JO - Advances in Microbial Physiology

JF - Advances in Microbial Physiology

ER -