The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary

Leeanne McGurk; George Tzolovsky; Norah Spears; Mary Bownes

doi:10.1016/j.modgep.2006.03.002

The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary

Leeanne McGurk, George Tzolovsky, Norah Spears, Mary Bownes (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

There are 16 classes of unconventional myosins. Class V myosins have been shown to be involved in transporting cargo to and from the cell periphery. Class VI myosins have also been shown to transport cargo from the cell periphery, although it seems that these proteins have many roles which include the mediation of cell migration and stereocillia stabilisation. With the requirement of myosin VI for Drosophila oogenesis, the localised expression of Myosin V in the developing egg chamber and recent mounting evidence which links myosin VI to the migration of human ovarian cancer cell lines, we wanted to investigate the expression pattern of these two myosin classes in the normal mouse ovary. Here we show that these myosins are expressed, localised and regulated within the oocyte and granulosa cells of the developing mouse follicle.

Original language	English
Pages (from-to)	900-907
Number of pages	8
Journal	Gene Expression Patterns
Volume	6
Issue number	8
Early online date	6 Mar 2006
DOIs	https://doi.org/10.1016/j.modgep.2006.03.002
Publication status	Published - 2 Oct 2006

Keywords

Class V and VI unconventional myosin
Genomic organisation
Immunohistochemistry
Mouse ovarian follicle development
RNA localisation

ASJC Scopus subject areas

Molecular Biology
Genetics
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.modgep.2006.03.002

Cite this

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title = "The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary",

abstract = "There are 16 classes of unconventional myosins. Class V myosins have been shown to be involved in transporting cargo to and from the cell periphery. Class VI myosins have also been shown to transport cargo from the cell periphery, although it seems that these proteins have many roles which include the mediation of cell migration and stereocillia stabilisation. With the requirement of myosin VI for Drosophila oogenesis, the localised expression of Myosin V in the developing egg chamber and recent mounting evidence which links myosin VI to the migration of human ovarian cancer cell lines, we wanted to investigate the expression pattern of these two myosin classes in the normal mouse ovary. Here we show that these myosins are expressed, localised and regulated within the oocyte and granulosa cells of the developing mouse follicle.",

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AU - McGurk, Leeanne

AU - Tzolovsky, George

AU - Spears, Norah

AU - Bownes, Mary

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AB - There are 16 classes of unconventional myosins. Class V myosins have been shown to be involved in transporting cargo to and from the cell periphery. Class VI myosins have also been shown to transport cargo from the cell periphery, although it seems that these proteins have many roles which include the mediation of cell migration and stereocillia stabilisation. With the requirement of myosin VI for Drosophila oogenesis, the localised expression of Myosin V in the developing egg chamber and recent mounting evidence which links myosin VI to the migration of human ovarian cancer cell lines, we wanted to investigate the expression pattern of these two myosin classes in the normal mouse ovary. Here we show that these myosins are expressed, localised and regulated within the oocyte and granulosa cells of the developing mouse follicle.

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KW - Immunohistochemistry

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KW - RNA localisation

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The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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