The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse

J. Watson; D. Godfrey; W. H. Stimson; J. J. F. Belch; R. D. Sturrock

doi:10.1016/0192-0561(88)90135-X

The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse

J. Watson, D. Godfrey, W. H. Stimson, J. J. F. Belch, R. D. Sturrock

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18 Citations (Scopus)

Abstract

The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P < 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P < 0.005).

Original language	English
Pages (from-to)	467-471
Number of pages	5
Journal	International Journal of Immunopharmacology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0192-0561(88)90135-X
Publication status	Published - 1988

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title = "The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse",

abstract = "The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P < 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P < 0.005).",

author = "J. Watson and D. Godfrey and Stimson, {W. H.} and Belch, {J. J. F.} and Sturrock, {R. D.}",

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T1 - The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse

AU - Watson, J.

AU - Godfrey, D.

AU - Stimson, W. H.

AU - Belch, J. J. F.

AU - Sturrock, R. D.

PY - 1988

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N2 - The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P < 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P < 0.005).

AB - The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P < 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P < 0.005).

U2 - 10.1016/0192-0561(88)90135-X

DO - 10.1016/0192-0561(88)90135-X

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JO - International Journal of Immunopharmacology

JF - International Journal of Immunopharmacology

IS - 4

ER -

The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse

Abstract

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