The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse

J. Watson, D. Godfrey, W. H. Stimson, J. J. F. Belch, R. D. Sturrock

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P < 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P < 0.005).

    Original languageEnglish
    Pages (from-to)467-471
    Number of pages5
    JournalInternational Journal of Immunopharmacology
    Volume10
    Issue number4
    DOIs
    Publication statusPublished - 1988

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