The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse

TY - JOUR

T1 - The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse

AU - Watson, J.

AU - Godfrey, D.

AU - Stimson, W. H.

AU - Belch, J. J. F.

AU - Sturrock, R. D.

PY - 1988

Y1 - 1988

N2 - The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P < 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P < 0.005).

AB - The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P < 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P < 0.005).

U2 - 10.1016/0192-0561(88)90135-X

DO - 10.1016/0192-0561(88)90135-X

M3 - Article

C2 - 3170058

SN - 0192-0561

VL - 10

SP - 467

EP - 471

JO - International Journal of Immunopharmacology

JF - International Journal of Immunopharmacology

IS - 4

ER -