The twentieth century struggle to decipher insulin signalling

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    185 Citations (Scopus)


    Following the discovery of insulin, it took the rest of the twentieth century to understand how this hormone regulates intracellular metabolism. What are the main discoveries that led to our current understanding of this process? And how is this new knowledge being exploited in an attempt to develop improved drugs to treat the epidemic of type-2 diabetes?

    Original languageEnglish
    Pages (from-to)867-873
    Number of pages7
    JournalNature Reviews Molecular Cell Biology
    Issue number11
    Publication statusPublished - 1 Nov 2006

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology


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