The type VI secretion system - a widespread and versatile cell targeting system

    Research output: Contribution to journalArticle

    92 Citations (Scopus)

    Abstract

    The Type VI secretion system (T6SS) is the most recently described of the Gram-negative bacterial secretion systems and is widely distributed amongst diverse species. T6SSs are currently believed to be complex molecular machines which inject effector proteins into target cells and which incorporate a bacteriophage-like cell-puncturing device. T6SSs have been implicated in eukaryotic cell targeting and virulence in a range of important pathogens. More recently, 'antibacterial' T6SSs have been reported, which are used to efficiently target competitor bacterial cells by the injection of antibacterial toxins. Although it is clear that T6SSs can be deployed as versatile weapons to compete with other bacteria or attack simple or higher eukaryotes, much remains to be determined about this intriguing system.
    Original languageEnglish
    Pages (from-to)640-654
    Number of pages15
    JournalResearch in Microbiology
    Volume164
    Issue number6
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Bacterial Secretion Systems
    Weapons
    Eukaryotic Cells
    Eukaryota
    Bacteriophages
    Virulence
    Bacteria
    Equipment and Supplies
    Injections
    Type VI Secretion Systems
    Proteins

    Cite this

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    The type VI secretion system - a widespread and versatile cell targeting system. / Coulthurst, Sarah J.

    In: Research in Microbiology, Vol. 164, No. 6, 2013, p. 640-654.

    Research output: Contribution to journalArticle

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