The under-representation of older people in clinical trials: Barriers and potential solutions

TY - JOUR

T1 - The under-representation of older people in clinical trials

T2 - Barriers and potential solutions

AU - Habicht, D. W.

AU - Witham, M. D.

AU - McMurdo, M. E. T.

PY - 2008/3

Y1 - 2008/3

N2 - Frail older people are still under-represented in clinical trials. The evidence-base for clinical decision-making in this age group is poor even though older patients are the core business of health services. We examine possible causes for the exclusion of older people from clinical trials and propose possible solutions for this unjust and inequitable situation. Some progress has been made but more needs done to ensure equality and uniformly high standards of health care for older people.

AB - Frail older people are still under-represented in clinical trials. The evidence-base for clinical decision-making in this age group is poor even though older patients are the core business of health services. We examine possible causes for the exclusion of older people from clinical trials and propose possible solutions for this unjust and inequitable situation. Some progress has been made but more needs done to ensure equality and uniformly high standards of health care for older people.

KW - older

KW - clinical trial

KW - enrolment

KW - recruitment

KW - PLACEBO-CONTROLLED TRIAL

KW - HEART-FAILURE

KW - CARDIOVASCULAR EVENTS

KW - SPIRONOLACTONE

KW - INDIVIDUALS

KW - STROKE

U2 - 10.1007/BF02982619

DO - 10.1007/BF02982619

M3 - Article

SN - 1279-7707

VL - 12

SP - 194

EP - 196

JO - Journal of Nutrition Health & Aging

JF - Journal of Nutrition Health & Aging

IS - 3

ER -