Very few physical or theoretical models have been developed to assist with product development for oral colonic drug delivery. The aim here is to develop a theoretical mathematical model to describe the geometry of the colon and the fluid flows within it. This is part of a project which aims to predict the distribution and residence time of dosage forms in the colon e.g. whether they will reach the mucosal layer of the colon wall.
Timmis, A., Smith, D. J., Bridson, R. H., Simmons, M. J. H., & Decent, S. P. (2010). The use of mathematical modelling to describe fluid flow within the colon. Journal of Pharmacy and Pharmacology, 62(10), 1311-1312. https://doi.org/10.1111/j.2042-7158.2010.01178.x