The use of transgenic animals to assess the role of metabolism in target organ toxicity

C. Ronald Wolf, Sandra J. Campbell, A. John Clark, Austin Smith, John O. Bishop, C. J. Henderson

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Citations (Scopus)

    Abstract

    To date, there are few reports on the use of transgenic animals to establish the biological role and the regulation of drug metabolizing enzymes. In vitro models such as mammalian, yeast, insect and bacterial systems represent rapid and simple methods for assessing the role of cytochrome P450s in drug metabolism and chemical carcinogenesis, but may not necessarily reflect the in vivo situation, where other factors such as drug disposition, governed by absorption, distribution and excretion, are important. In vivo models provide the opportunity for the study of the biological effects of gene expression under more physiologically relevant conditions, and also allow the inclusion of pharmacotoxicological endpoints.
    Original languageEnglish
    Title of host publicationDiversification in Toxicology — Man and Environment
    Subtitle of host publicationProceedings of the 1997 EUROTOX Congress Meeting Held in Århus, Denmark, June 25–28, 1997
    EditorsJürg P. Seiler, Judith L. Autrup, Herman Autrup
    Place of PublicationBerlin
    PublisherSpringer Heidelberg
    Pages443-453
    Number of pages11
    Volume20
    Edition1
    ISBN (Electronic)978-3-642-46856-8
    ISBN (Print)978-3-642-46858-2
    DOIs
    Publication statusPublished - 1998

    Publication series

    NameArchives of toxicology. Supplement.
    PublisherSpringer-Verlag
    ISSN (Print)0171-9750

    ASJC Scopus subject areas

    • General Medicine

    Fingerprint

    Dive into the research topics of 'The use of transgenic animals to assess the role of metabolism in target organ toxicity'. Together they form a unique fingerprint.

    Cite this