The use of transgenic animals to assess the role of metabolism in target organ toxicity

C. Ronald Wolf, Sandra J. Campbell, A. John Clark, Austin Smith, John O. Bishop, C. J. Henderson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)


To date, there are few reports on the use of transgenic animals to establish the biological role and the regulation of drug metabolizing enzymes. In vitro models such as mammalian, yeast, insect and bacterial systems represent rapid and simple methods for assessing the role of cytochrome P450s in drug metabolism and chemical carcinogenesis, but may not necessarily reflect the in vivo situation, where other factors such as drug disposition, governed by absorption, distribution and excretion, are important. In vivo models provide the opportunity for the study of the biological effects of gene expression under more physiologically relevant conditions, and also allow the inclusion of pharmacotoxicological endpoints.
Original languageEnglish
Title of host publicationDiversification in Toxicology — Man and Environment
Subtitle of host publicationProceedings of the 1997 EUROTOX Congress Meeting Held in Århus, Denmark, June 25–28, 1997
EditorsJürg P. Seiler, Judith L. Autrup, Herman Autrup
Place of PublicationBerlin
PublisherSpringer Heidelberg
Number of pages11
ISBN (Electronic)978-3-642-46856-8
ISBN (Print)978-3-642-46858-2
Publication statusPublished - 1998

Publication series

NameArchives of toxicology. Supplement.
ISSN (Print)0171-9750

ASJC Scopus subject areas

  • General Medicine


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