The Use of Transgenic Animals to Study Drug Metabolism

Colin J. Henderson; C. Roland Wolf; Nico Scheer

doi:10.3109/9781420076486-28

The Use of Transgenic Animals to Study Drug Metabolism

Cancer Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

As with many other areas of biological science, the field of toxicology and molecular pharmacology has been revolutionized by transgenic technology over the past two decades. The ability to express foreign genes, delete-specifically, in certain tissues or at defined times or globally in all cells-or mutate specific endogenous genes in a living multicellular organism, has vastly added to our knowledge of drug-metabolizing enzymes-how they are expressed and regulated, how they function, and how they interact with each other. The majority of this work has been done in the mouse, and gene knockouts/knock-ins almost exclusively so, for both historical and technological reasons. BACKGROUND TO TRANSGENIC TECHNOLOGY.

Original language	English
Title of host publication	Handbook of Drug Metabolism, Second Edition
Publisher	CRC Press
Pages	637-658
Number of pages	22
ISBN (Electronic)	9781420076486
ISBN (Print)	9781482262049
DOIs	https://doi.org/10.3109/9781420076486-28
Publication status	Published - 1 Jan 2008

ASJC Scopus subject areas

General Medicine
General Pharmacology, Toxicology and Pharmaceutics

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10.3109/9781420076486-28

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AB - As with many other areas of biological science, the field of toxicology and molecular pharmacology has been revolutionized by transgenic technology over the past two decades. The ability to express foreign genes, delete-specifically, in certain tissues or at defined times or globally in all cells-or mutate specific endogenous genes in a living multicellular organism, has vastly added to our knowledge of drug-metabolizing enzymes-how they are expressed and regulated, how they function, and how they interact with each other. The majority of this work has been done in the mouse, and gene knockouts/knock-ins almost exclusively so, for both historical and technological reasons. BACKGROUND TO TRANSGENIC TECHNOLOGY.

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PB - CRC Press

ER -

The Use of Transgenic Animals to Study Drug Metabolism

Abstract

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