TY - JOUR
T1 - The wt1-heterozygous mouse
T2 - a model to study the development of glomerular sclerosis
AU - Menke, Aswin L
AU - IJpenberg, Annemieke
AU - Fleming, Stewart
AU - Ross, Allyson
AU - Medine, Claire N
AU - Patek, Charles E
AU - Spraggon, Lee
AU - Hughes, Jeremy
AU - Clarke, Alan R
AU - Hastie, Nicholas D
N1 - Copyright 2003 John Wiley & Sons, Ltd.
PY - 2003
Y1 - 2003
N2 - In the present study, it is shown that mice heterozygous for wt1 develop glomerular sclerosis and the nature and time course of events leading to the glomerular scarring are determined. Wt1-heterozygous (wt1het) mice and their wild-type littermates were closely monitored from birth and plasma levels of urea, creatinine, and albumin were compared with histological data and clinical features. One of the first indications of nephropathy in the wt1het mouse was the development of proteinuria, accompanied by progressive elevation of the plasma levels of urea and creatinine. Subsequently, the mice developed albuminuria, which correlated with thickening of the glomerular basement membrane and fusion of the podocyte foot processes. Glomerulosclerosis was a relatively late event, accompanied by severe albuminuria and loss of WT1, nephrin, CD2AP, and alpha-actinin-4.
AB - In the present study, it is shown that mice heterozygous for wt1 develop glomerular sclerosis and the nature and time course of events leading to the glomerular scarring are determined. Wt1-heterozygous (wt1het) mice and their wild-type littermates were closely monitored from birth and plasma levels of urea, creatinine, and albumin were compared with histological data and clinical features. One of the first indications of nephropathy in the wt1het mouse was the development of proteinuria, accompanied by progressive elevation of the plasma levels of urea and creatinine. Subsequently, the mice developed albuminuria, which correlated with thickening of the glomerular basement membrane and fusion of the podocyte foot processes. Glomerulosclerosis was a relatively late event, accompanied by severe albuminuria and loss of WT1, nephrin, CD2AP, and alpha-actinin-4.
U2 - 10.1002/path.1390
DO - 10.1002/path.1390
M3 - Article
C2 - 12898605
SN - 0022-3417
VL - 200
SP - 667
EP - 674
JO - Journal of Pathology
JF - Journal of Pathology
IS - 5
ER -