Projects per year
Abstract
As a part of the body that is considered external, the gastrointestinal (GI) tract should allow easy access, but it remained relatively obscure, particularly the small intestine, until video capsule endoscopy (VCE) emerged in the past 20 years, uniquely able to view the entire length routinely. Additionally, drawing on contemporary topics including miniaturisation of electronics, wireless communications and efficient electrical power delivery, VCE provides a model for future devices. However, research in therapeutic capsule endoscopy (TCE) has been limited and poorly integrated with diagnostics. This chapter reviews relevant progress, highlighting ultrasound (US) as particularly promising for GI TCE. A description of the GI tract at different length scales is given, including the common, multi-layered structure maintained from mouth to anus and its variation down to cellular and sub-cellular level. Recent developments in multimodal capsule endoscopy are described, including US for imaging within tissue, and targeted drug delivery (TDD) is highlighted for TCE, particularly with US-mediation, because of the potential perforation associated with simpler ablation techniques. This is exemplified by a proof-of-concept theranostic device with the potential to treat conditions such as inflammatory bowel disease and colon cancer. Finally, with significant development ahead, relevant areas are highlighted, including further capsule development and nanotechnology.
Original language | English |
---|---|
Title of host publication | Theranostics and Image Guided Drug Delivery |
Editors | Maya Thanou |
Place of Publication | United Kingdom |
Publisher | Royal Society of Chemistry |
Pages | 182-210 |
Number of pages | 29 |
ISBN (Electronic) | 9781788013932 |
ISBN (Print) | 9781782624660, 9781788010597 |
DOIs | |
Publication status | Published - 5 Jan 2018 |
Publication series
Name | Drug Discovery |
---|---|
Publisher | Royal Society of Chemistry |
Number | 63 |
ASJC Scopus subject areas
- Drug Discovery
Fingerprint
Dive into the research topics of 'Theranostics in the Gut'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)
Cochran, S. (Investigator), Corner, G. (Investigator), Cuschieri, A. (Investigator), Nathke, I. (Investigator) & Steele, B. (Investigator)
Engineering and Physical Sciences Research Council
27/05/13 → 14/12/18
Project: Research