Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability

Francisco Bustos (Lead / Corresponding author), Greg M. Findlay (Lead / Corresponding author)

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Abstract

Intellectual disability (ID) represents a major burden on healthcare systems in the developed world. However, there is a disconnect between our knowledge of genes that are mutated in ID and our understanding of the underpinning molecular mechanisms that cause these disorders. We argue that elucidating the signalling and transcriptional networks that are dysregulated in patients will afford new therapeutic opportunities.

Original languageEnglish
Number of pages7
JournalFEBS Journal
Early online date24 Feb 2022
DOIs
Publication statusE-pub ahead of print - 24 Feb 2022

Keywords

  • intellectual disability
  • neurodevelopmental disorders
  • post-translational modification
  • signal transduction
  • stem cells

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