Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability

Francisco Bustos; Greg M. Findlay

doi:10.1111/febs.16411

Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability

Francisco Bustos (Lead / Corresponding author), Greg M. Findlay (Lead / Corresponding author)

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Abstract

Intellectual disability (ID) represents a major burden on healthcare systems in the developed world. However, there is a disconnect between our knowledge of genes that are mutated in ID and our understanding of the underpinning molecular mechanisms that cause these disorders. We argue that elucidating the signalling and transcriptional networks that are dysregulated in patients will afford new therapeutic opportunities.

Original language	English
Pages (from-to)	1454-1460
Number of pages	7
Journal	FEBS Journal
Volume	290
Issue number	6
Early online date	24 Feb 2022
DOIs	https://doi.org/10.1111/febs.16411
Publication status	Published - Mar 2023

Keywords

intellectual disability
neurodevelopmental disorders
post-translational modification
signal transduction
stem cells

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1111/febs.16411Licence: CC BY

Final Published VersionFinal published version, 313 KBLicence: CC BY

Cite this

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abstract = "Intellectual disability (ID) represents a major burden on healthcare systems in the developed world. However, there is a disconnect between our knowledge of genes that are mutated in ID and our understanding of the underpinning molecular mechanisms that cause these disorders. We argue that elucidating the signalling and transcriptional networks that are dysregulated in patients will afford new therapeutic opportunities.",

keywords = "intellectual disability, neurodevelopmental disorders, post-translational modification, signal transduction, stem cells",

author = "Francisco Bustos and Findlay, {Greg M.}",

note = "Funding Information: GMF is supported by a Wellcome Trust/Royal Society Sir Henry Dale Fellowship (211209/Z/ 18/Z). FB is supported by start-up funds from Sanford Research. Copyright: {\textcopyright} 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.",

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AU - Findlay, Greg M.

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AB - Intellectual disability (ID) represents a major burden on healthcare systems in the developed world. However, there is a disconnect between our knowledge of genes that are mutated in ID and our understanding of the underpinning molecular mechanisms that cause these disorders. We argue that elucidating the signalling and transcriptional networks that are dysregulated in patients will afford new therapeutic opportunities.

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Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability

Abstract

Keywords

ASJC Scopus subject areas

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Functions and Applications of a Novel Pluripotency Signalling Pathway (Sir Henry Dale Fellowship)

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Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability

Abstract

Keywords

ASJC Scopus subject areas

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Other files and links

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Functions and Applications of a Novel Pluripotency Signalling Pathway (Sir Henry Dale Fellowship)

Cite this