Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability

Francisco Bustos (Lead / Corresponding author), Greg M. Findlay (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

25 Downloads (Pure)

Abstract

Intellectual disability (ID) represents a major burden on healthcare systems in the developed world. However, there is a disconnect between our knowledge of genes that are mutated in ID and our understanding of the underpinning molecular mechanisms that cause these disorders. We argue that elucidating the signalling and transcriptional networks that are dysregulated in patients will afford new therapeutic opportunities.

Original languageEnglish
Pages (from-to)1454-1460
Number of pages7
JournalFEBS Journal
Volume290
Issue number6
Early online date24 Feb 2022
DOIs
Publication statusPublished - Mar 2023

Keywords

  • intellectual disability
  • neurodevelopmental disorders
  • post-translational modification
  • signal transduction
  • stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability'. Together they form a unique fingerprint.

Cite this