TY - GEN
T1 - Thiotaurine
T2 - From Chemical and Biological Properties to Role in H²S Signaling
AU - Baseggio Conrado, Alessia
AU - Capuozzo, Elisabetta
AU - Mosca, Luciana
AU - Francioso, Antonio
AU - Fontana, Mario
PY - 2019
Y1 - 2019
N2 - In the last decade thiotaurine, 2-aminoethane thiosulfonate, has been investigated as an inflammatory modulating agent as a result of its ability to release hydrogen sulfide (H2S) known to play regulatory roles in inflammation. Thiotaurine can be included in the "taurine family" due to structural similarity to taurine and hypotaurine, and is characterized by the presence of a sulfane sulfur moiety. Thiotaurine can be produced by different pathways, such as the spontaneous transsulfuration between thiocysteine - a persulfide analogue of cysteine - and hypotaurine as well as in vivo from cystine. Moreover, the enzymatic oxidation of cysteamine to hypotaurine and thiotaurine in the presence of inorganic sulfur can occur in animal tissues and last but not least thiotaurine can be generated by the transfer of sulfur from mercaptopyruvate to hypotaurine catalyzed by a sulfurtransferase. Thiotaurine is an effective antioxidant agent as demonstrated by its ability to counteract the damage caused by pro-oxidants in the rat. Recently, we observed the influence of thiotaurine on human neutrophils functional responses. In particular, thiotaurine has been found to prevent human neutrophil spontaneous apoptosis suggesting an alternative or additional role to its antioxidant activity. It is likely that the sulfane sulfur of thiotaurine may modulate neutrophil activation via persulfidation of target proteins. In conclusion, thiotaurine can represent a biologically relevant sulfur donor acting as a biological intermediate in the transport, storage and release of sulfide.
AB - In the last decade thiotaurine, 2-aminoethane thiosulfonate, has been investigated as an inflammatory modulating agent as a result of its ability to release hydrogen sulfide (H2S) known to play regulatory roles in inflammation. Thiotaurine can be included in the "taurine family" due to structural similarity to taurine and hypotaurine, and is characterized by the presence of a sulfane sulfur moiety. Thiotaurine can be produced by different pathways, such as the spontaneous transsulfuration between thiocysteine - a persulfide analogue of cysteine - and hypotaurine as well as in vivo from cystine. Moreover, the enzymatic oxidation of cysteamine to hypotaurine and thiotaurine in the presence of inorganic sulfur can occur in animal tissues and last but not least thiotaurine can be generated by the transfer of sulfur from mercaptopyruvate to hypotaurine catalyzed by a sulfurtransferase. Thiotaurine is an effective antioxidant agent as demonstrated by its ability to counteract the damage caused by pro-oxidants in the rat. Recently, we observed the influence of thiotaurine on human neutrophils functional responses. In particular, thiotaurine has been found to prevent human neutrophil spontaneous apoptosis suggesting an alternative or additional role to its antioxidant activity. It is likely that the sulfane sulfur of thiotaurine may modulate neutrophil activation via persulfidation of target proteins. In conclusion, thiotaurine can represent a biologically relevant sulfur donor acting as a biological intermediate in the transport, storage and release of sulfide.
KW - Antioxidant
KW - H S donor
KW - H S signaling
KW - Hydrogen sulfide
KW - Hypotaurine
KW - Inflammation
KW - Neutrophils
KW - Reactive sulfur species
KW - Sulfane sulfur
KW - Thiotaurine
UR - http://www.scopus.com/inward/record.url?scp=85071772236&partnerID=8YFLogxK
U2 - 10.1007/978-981-13-8023-5_66
DO - 10.1007/978-981-13-8023-5_66
M3 - Conference contribution
C2 - 31468446
SN - 9789811380228
VL - 1155
T3 - Advances in Experimental Medicine and Biology
SP - 755
EP - 771
BT - Taurine 11
A2 - Hu, Jianmin
A2 - Piao, Fengyuan
A2 - Schaffer, Stephen W.
A2 - El Idrissi, Abdeslem
A2 - Wu, Jang-Yen
PB - Springer
CY - Singapore
ER -