Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus

TY - JOUR

T1 - Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus

AU - Bartual, Sergio G.

AU - Alcorlo, Martín

AU - Martínez-Caballero, Siseth

AU - Molina, Rafael

AU - Hermoso, Juan A.

PY - 2018/8

Y1 - 2018/8

N2 - Bacterial lipoproteins (Lpp) compose a large family of surface-exposed proteins that are involved in diverse, but critical, cellular functions spanning from fitness to virulence. All of them present a common signature, a sequence motif, known as LipoBox, containing an invariant Cys residue that allows the protein to be covalently bound to the membrane through a thioether linkage. Despite the abundance and relevance of Lpp, there is a scarcity of structural and functional information for this family of proteins. In this review, the updated structural and functional data for Lpp from two Gram-positive pathogenic model organisms, Staphylococcus aureus and Streptococcus pneumoniae is presented. The available structural information offers a glimpse over the Lpp functional mechanisms. Their relevance in bacterial fitness, and also in virulence and host-pathogen interactions, reveals lipoproteins as very attractive targets for designing of novel antimicrobials, and interesting candidates as novel vaccine antigens.

AB - Bacterial lipoproteins (Lpp) compose a large family of surface-exposed proteins that are involved in diverse, but critical, cellular functions spanning from fitness to virulence. All of them present a common signature, a sequence motif, known as LipoBox, containing an invariant Cys residue that allows the protein to be covalently bound to the membrane through a thioether linkage. Despite the abundance and relevance of Lpp, there is a scarcity of structural and functional information for this family of proteins. In this review, the updated structural and functional data for Lpp from two Gram-positive pathogenic model organisms, Staphylococcus aureus and Streptococcus pneumoniae is presented. The available structural information offers a glimpse over the Lpp functional mechanisms. Their relevance in bacterial fitness, and also in virulence and host-pathogen interactions, reveals lipoproteins as very attractive targets for designing of novel antimicrobials, and interesting candidates as novel vaccine antigens.

KW - Lipoproteins

KW - Protein structure

KW - Staphylococcus aureus

KW - Streptococcus pneumoniae

KW - Virulence

U2 - 10.1016/j.ijmm.2017.10.003

DO - 10.1016/j.ijmm.2017.10.003

M3 - Article

C2 - 29100886

AN - SCOPUS:85033692456

SN - 1438-4221

VL - 308

SP - 692

EP - 704

JO - International Journal of Medical Microbiology

JF - International Journal of Medical Microbiology

IS - 6

ER -