Three wise centromere functions: see no error, hear no break, speak no delay

Tomoyuki U. Tanaka, Lesley Clayton, Toyoaki Natsume

    Research output: Contribution to journalReview article

    9 Citations (Scopus)

    Abstract

    The main function of the centromere is to promote kinetochore assembly for spindle microtubule attachment. Two additional functions of the centromere, however, are becoming increasingly clear: facilitation of robust sister-chromatid cohesion at pericentromeres and advancement of replication of centromeric regions. The combination of these three centromere functions ensures correct chromosome segregation during mitosis. Here, we review the mechanisms of the kinetochore-microtubule interaction, focusing on sister-kinetochore bi-orientation (or chromosome bi-orientation). We also discuss the biological importance of robust pericentromeric cohesion and early centromere replication, as well as the mechanisms orchestrating these two functions at the microtubule attachment site.
    Original languageEnglish
    Pages (from-to)1073-1083
    Number of pages11
    JournalEMBO Reports
    Volume14
    Issue number12
    DOIs
    Publication statusPublished - Dec 2013

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    Centromere
    Kinetochores
    Microtubules
    Chromosomes
    Chromosome Segregation
    Chromatids
    Mitosis

    Cite this

    Tanaka, Tomoyuki U. ; Clayton, Lesley ; Natsume, Toyoaki. / Three wise centromere functions : see no error, hear no break, speak no delay. In: EMBO Reports. 2013 ; Vol. 14, No. 12. pp. 1073-1083.
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    abstract = "The main function of the centromere is to promote kinetochore assembly for spindle microtubule attachment. Two additional functions of the centromere, however, are becoming increasingly clear: facilitation of robust sister-chromatid cohesion at pericentromeres and advancement of replication of centromeric regions. The combination of these three centromere functions ensures correct chromosome segregation during mitosis. Here, we review the mechanisms of the kinetochore-microtubule interaction, focusing on sister-kinetochore bi-orientation (or chromosome bi-orientation). We also discuss the biological importance of robust pericentromeric cohesion and early centromere replication, as well as the mechanisms orchestrating these two functions at the microtubule attachment site.",
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    Three wise centromere functions : see no error, hear no break, speak no delay. / Tanaka, Tomoyuki U.; Clayton, Lesley; Natsume, Toyoaki.

    In: EMBO Reports, Vol. 14, No. 12, 12.2013, p. 1073-1083.

    Research output: Contribution to journalReview article

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    T1 - Three wise centromere functions

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    AU - Tanaka, Tomoyuki U.

    AU - Clayton, Lesley

    AU - Natsume, Toyoaki

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    N2 - The main function of the centromere is to promote kinetochore assembly for spindle microtubule attachment. Two additional functions of the centromere, however, are becoming increasingly clear: facilitation of robust sister-chromatid cohesion at pericentromeres and advancement of replication of centromeric regions. The combination of these three centromere functions ensures correct chromosome segregation during mitosis. Here, we review the mechanisms of the kinetochore-microtubule interaction, focusing on sister-kinetochore bi-orientation (or chromosome bi-orientation). We also discuss the biological importance of robust pericentromeric cohesion and early centromere replication, as well as the mechanisms orchestrating these two functions at the microtubule attachment site.

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