Three wise centromere functions: see no error, hear no break, speak no delay

Tomoyuki U. Tanaka, Lesley Clayton, Toyoaki Natsume

    Research output: Contribution to journalReview articlepeer-review

    18 Citations (Scopus)


    The main function of the centromere is to promote kinetochore assembly for spindle microtubule attachment. Two additional functions of the centromere, however, are becoming increasingly clear: facilitation of robust sister-chromatid cohesion at pericentromeres and advancement of replication of centromeric regions. The combination of these three centromere functions ensures correct chromosome segregation during mitosis. Here, we review the mechanisms of the kinetochore-microtubule interaction, focusing on sister-kinetochore bi-orientation (or chromosome bi-orientation). We also discuss the biological importance of robust pericentromeric cohesion and early centromere replication, as well as the mechanisms orchestrating these two functions at the microtubule attachment site.
    Original languageEnglish
    Pages (from-to)1073-1083
    Number of pages11
    JournalEMBO Reports
    Issue number12
    Publication statusPublished - Dec 2013


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