Thrombocytosis during Stable State Predicts Mortality in Bronchiectasis

Stefano Aliberti, Giovanni Sotgiu, Andrea Gramegna, Melissa J. McDonnell, Eva Polverino, Antoni Torres, Pieter C. Goeminne, Katerina Dimakou, Michal Shteinberg, Oriol Sibila, Valentina Conio, Thomas C. Fardon, Robert Rutherford, Simone Dore, Laura Saderi, Paola Faverio, Francesco Amati, Angelo G. Corsico, Francesco Blasi, James D. Chalmers

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Rationale: Although platelets are considered key inflammatory mediators in respiratory diseases, their role in bronchiectasis has not been fully explored.

Objectives: We hypothesized that thrombocytosis in stable state may be associated with bronchiectasis severity and worse clinical outcomes.

Methods: Patients with bronchiectasis have been enrolled from 10 centers in Europe and Israel, with platelet count recorded during stable state. The primary outcome was 5-year all-cause mortality. Secondary outcomes included exacerbations, hospitalizations, and mortality at 1, 2, and 3-year follow-up. Analyses were conducted using logistic regression after adjustment for confounding variables.

Results: Among the 1,771 patients (median age, 67 yr; 63.4% female) included, 136 (7.7%) had thrombocytosis. Patients with thrombocytosis had a significantly higher disease severity, worse quality of life, higher number of exacerbations and hospitalizations, and higher mortality rate at both 3-year (23 [22.8%] vs. 83 [8.5%], respectively; P,0.01) and 5-year (26 [35.1%] vs. 116 [15.9%], respectively; P,0.01) in comparison with those with normal platelet count. Thrombocytosis was significantly associated with hospitalizations because of severe exacerbations (odds ratio [OR], 1.83; 95% confidence interval [CI], 1.20-2.79; P=0.01) after 1-year followup, as well as increased 3-year (OR, 3.06; 95% CI, 1.74-5.39; P,0.01) and 5-year (OR, 2.46; 95% CI, 1.39-4.37; P,0.01) mortality.

Conclusions: Platelets represent a cheap and easy-to-evaluate biomarker, and the presence of thrombocytosis during stable state is associated with disease severity, hospitalizations because of exacerbations, poor quality of life, and mortality in adults with bronchiectasis

Original languageEnglish
Pages (from-to)1316-1325
Number of pages10
JournalAnnals of the American Thoracic Society
Issue number8
Early online date28 Jan 2021
Publication statusPublished - Aug 2021


  • Bronchiectasis
  • Mortality
  • Platelets

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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