Abstract
Field potential recordings were made from the dentate gyrus of urethane-anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was unaffected. These results indicate that dentate LTP in vivo exhibits a similar limited time window of vulnerability to reversal by low frequency stimulation to that previously reported in area CA1 in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 3775-81 |
| Number of pages | 7 |
| Journal | NeuroReport |
| Volume | 9 |
| Issue number | 17 |
| Publication status | Published - Dec 1998 |
Keywords
- Analysis of Variance
- Animals
- Dentate Gyrus/physiology
- Electric Stimulation
- Excitatory Postsynaptic Potentials
- Linear Models
- Long-Term Potentiation
- Male
- Rats
- Tetany
- Time Factors