Time-dependent reversal of dentate LTP by 5 Hz stimulation

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28 Citations (Scopus)

Abstract

Field potential recordings were made from the dentate gyrus of urethane-anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was unaffected. These results indicate that dentate LTP in vivo exhibits a similar limited time window of vulnerability to reversal by low frequency stimulation to that previously reported in area CA1 in vitro.

Original languageEnglish
Pages (from-to)3775-81
Number of pages7
JournalNeuroReport
Volume9
Issue number17
Publication statusPublished - Dec 1998

Keywords

  • Analysis of Variance
  • Animals
  • Dentate Gyrus/physiology
  • Electric Stimulation
  • Excitatory Postsynaptic Potentials
  • Linear Models
  • Long-Term Potentiation
  • Male
  • Rats
  • Tetany
  • Time Factors

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