Time-dependent reversal of dentate LTP by 5 Hz stimulation

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    Abstract

    Field potential recordings were made from the dentate gyrus of urethane-anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was unaffected. These results indicate that dentate LTP in vivo exhibits a similar limited time window of vulnerability to reversal by low frequency stimulation to that previously reported in area CA1 in vitro.

    Original languageEnglish
    Pages (from-to)3775-81
    Number of pages7
    JournalNeuroReport
    Volume9
    Issue number17
    Publication statusPublished - Dec 1998

    Keywords

    • Analysis of Variance
    • Animals
    • Dentate Gyrus/physiology
    • Electric Stimulation
    • Excitatory Postsynaptic Potentials
    • Linear Models
    • Long-Term Potentiation
    • Male
    • Rats
    • Tetany
    • Time Factors

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