Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

K. Ehrlich, H. Fleming, S. McAughtrie, A. Kufcsák, N. Krstajic, C. J. Campbell, R. K. Henderson, K. Dhaliwal, R. R. Thomson, M. G. Tanner

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    Abstract

    We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

    Original languageEnglish
    Title of host publicationBiophotonics
    Subtitle of host publicationPhotonic Solutions for Better Health Care VI
    EditorsJurgen Popp, Valery V. Tuchin, Francesco Saverio Pavone
    PublisherSPIE-International Society for Optical Engineering
    Volume10685
    ISBN (Electronic)9781510618961
    ISBN (Print)9781510618961
    DOIs
    Publication statusPublished - 17 May 2018
    EventBiophotonics: Photonic Solutions for Better Health Care VI 2018 - Strasbourg, France
    Duration: 23 Apr 201826 Apr 2018

    Conference

    ConferenceBiophotonics: Photonic Solutions for Better Health Care VI 2018
    CountryFrance
    CityStrasbourg
    Period23/04/1826/04/18

    Keywords

    • Detector arrays
    • Fibre optic sensors
    • Photon counting
    • Raman spectroscopy
    • Surface-enhanced Raman scattering
    • Time-resolved spectroscopy

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