Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

K. Ehrlich; H. Fleming; S. McAughtrie; A. Kufcsák; N. Krstajic; C. J. Campbell; R. K. Henderson; K. Dhaliwal; R. R. Thomson; M. G. Tanner

doi:10.1117/12.2307334

Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

K. Ehrlich, H. Fleming, S. McAughtrie, A. Kufcsák, N. Krstajic, C. J. Campbell, R. K. Henderson, K. Dhaliwal, R. R. Thomson, M. G. Tanner

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Abstract

We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

Original language	English
Title of host publication	Biophotonics
Subtitle of host publication	Photonic Solutions for Better Health Care VI
Editors	Jurgen Popp, Valery V. Tuchin, Francesco Saverio Pavone
Publisher	SPIE-International Society for Optical Engineering
Volume	10685
ISBN (Electronic)	9781510618961
ISBN (Print)	9781510618961
DOIs	https://doi.org/10.1117/12.2307334
Publication status	Published - 17 May 2018
Event	Biophotonics: Photonic Solutions for Better Health Care VI 2018 - Strasbourg, France Duration: 23 Apr 2018 → 26 Apr 2018

Conference

Conference	Biophotonics: Photonic Solutions for Better Health Care VI 2018
Country/Territory	France
City	Strasbourg
Period	23/04/18 → 26/04/18

Keywords

Detector arrays
Fibre optic sensors
Photon counting
Raman spectroscopy
Surface-enhanced Raman scattering
Time-resolved spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.2307334

Author Accepted ManuscriptAccepted author manuscript, 5.52 MBLicence: CC BY-NC-ND

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Ehrlich, K., Fleming, H., McAughtrie, S., Kufcsák, A., Krstajic, N., Campbell, C. J., Henderson, R. K., Dhaliwal, K., Thomson, R. R., & Tanner, M. G. (2018). Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. In J. Popp, V. V. Tuchin, & F. S. Pavone (Eds.), Biophotonics: Photonic Solutions for Better Health Care VI (Vol. 10685). Article 106850Q SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2307334

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title = "Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design",

abstract = "We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.",

keywords = "Detector arrays, Fibre optic sensors, Photon counting, Raman spectroscopy, Surface-enhanced Raman scattering, Time-resolved spectroscopy",

author = "K. Ehrlich and H. Fleming and S. McAughtrie and A. Kufcs{\'a}k and N. Krstajic and Campbell, {C. J.} and Henderson, {R. K.} and K. Dhaliwal and Thomson, {R. R.} and Tanner, {M. G.}",

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month = may,

day = "17",

doi = "10.1117/12.2307334",

language = "English",

isbn = "9781510618961",

volume = "10685",

editor = "Jurgen Popp and Tuchin, {Valery V.} and Pavone, {Francesco Saverio}",

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publisher = "SPIE-International Society for Optical Engineering",

note = "Biophotonics: Photonic Solutions for Better Health Care VI 2018 ; Conference date: 23-04-2018 Through 26-04-2018",

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Ehrlich, K, Fleming, H, McAughtrie, S, Kufcsák, A, Krstajic, N, Campbell, CJ, Henderson, RK, Dhaliwal, K, Thomson, RR & Tanner, MG 2018, Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. in J Popp, VV Tuchin & FS Pavone (eds), Biophotonics: Photonic Solutions for Better Health Care VI. vol. 10685, 106850Q, SPIE-International Society for Optical Engineering, Biophotonics: Photonic Solutions for Better Health Care VI 2018, Strasbourg, France, 23/04/18. https://doi.org/10.1117/12.2307334

Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. / Ehrlich, K.; Fleming, H.; McAughtrie, S. et al.
Biophotonics: Photonic Solutions for Better Health Care VI. ed. / Jurgen Popp; Valery V. Tuchin; Francesco Saverio Pavone. Vol. 10685 SPIE-International Society for Optical Engineering, 2018. 106850Q.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

AU - Ehrlich, K.

AU - Fleming, H.

AU - McAughtrie, S.

AU - Kufcsák, A.

AU - Krstajic, N.

AU - Campbell, C. J.

AU - Henderson, R. K.

AU - Dhaliwal, K.

AU - Thomson, R. R.

AU - Tanner, M. G.

PY - 2018/5/17

Y1 - 2018/5/17

N2 - We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

AB - We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

KW - Detector arrays

KW - Fibre optic sensors

KW - Photon counting

KW - Raman spectroscopy

KW - Surface-enhanced Raman scattering

KW - Time-resolved spectroscopy

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U2 - 10.1117/12.2307334

DO - 10.1117/12.2307334

M3 - Conference contribution

AN - SCOPUS:85049167642

SN - 9781510618961

VL - 10685

BT - Biophotonics

A2 - Popp, Jurgen

A2 - Tuchin, Valery V.

A2 - Pavone, Francesco Saverio

PB - SPIE-International Society for Optical Engineering

T2 - Biophotonics: Photonic Solutions for Better Health Care VI 2018

Y2 - 23 April 2018 through 26 April 2018

ER -

Ehrlich K, Fleming H, McAughtrie S, Kufcsák A, Krstajic N, Campbell CJ et al. Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. In Popp J, Tuchin VV, Pavone FS, editors, Biophotonics: Photonic Solutions for Better Health Care VI. Vol. 10685. SPIE-International Society for Optical Engineering. 2018. 106850Q doi: 10.1117/12.2307334

Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

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Keywords

ASJC Scopus subject areas

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