TY - JOUR
T1 - Time trends in diagnostic testing for primary ciliary dyskinesia in Europe
AU - Halbeisen, Florian S.
AU - Shoemark, Amelia
AU - Barbato, Angelo
AU - Boon, Mieke
AU - Carr, Siobhan
AU - Crowley, Suzanne
AU - Hirst, Rob
AU - Karadag, Bulent
AU - Koerner-Rettberg, Cordula
AU - Loebinger, Michael R.
AU - Lucas, Jane S.
AU - Maitre, Bernard
AU - Mazurek, Henryk
AU - Özçelik, Uğur
AU - Martinů, Vendula
AU - Schwerk, Nicolaus
AU - Thouvenin, Guillaume
AU - Tschanz, Stefan A.
AU - Yiallouros, Panayiotis
AU - Goutaki, Myrofora
AU - Kuehni, Claudia E.
PY - 2019/10
Y1 - 2019/10
N2 - Despite recent advances in diagnostic methods, diagnosis of primary ciliary dyskinesia (PCD) remains complex. We need a combination of different diagnostic tests, and all have their limitations [1]. In 2009, the first European Respiratory Society Task Force (ERS TF) on PCD in children published recommendations [2], suggesting that: 1) Nasal nitric oxide (nNO) should be measured to screen for PCD in patients aged ≥5 years [3]; and 2) video microscopy (VM) analysis of ciliary beat pattern and frequency [4] plus electron microscopy (EM) [5] should be the key confirmatory diagnostic tests. Genetic testing was not recommended as part of the initial diagnostic testing, but as additional test for inconclusive cases. The recommended test combination was nNO, VM and EM for patients aged ≥5 years and VM plus EM for younger patients.
AB - Despite recent advances in diagnostic methods, diagnosis of primary ciliary dyskinesia (PCD) remains complex. We need a combination of different diagnostic tests, and all have their limitations [1]. In 2009, the first European Respiratory Society Task Force (ERS TF) on PCD in children published recommendations [2], suggesting that: 1) Nasal nitric oxide (nNO) should be measured to screen for PCD in patients aged ≥5 years [3]; and 2) video microscopy (VM) analysis of ciliary beat pattern and frequency [4] plus electron microscopy (EM) [5] should be the key confirmatory diagnostic tests. Genetic testing was not recommended as part of the initial diagnostic testing, but as additional test for inconclusive cases. The recommended test combination was nNO, VM and EM for patients aged ≥5 years and VM plus EM for younger patients.
UR - http://www.scopus.com/inward/record.url?scp=85074119256&partnerID=8YFLogxK
U2 - 10.1183/13993003.00528-2019
DO - 10.1183/13993003.00528-2019
M3 - Article
C2 - 31273043
SN - 0903-1936
VL - 54
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 4
M1 - 1900528
ER -