Timed degradation of Mcl-1 controls mitotic cell death

Paul R. Clarke (Lead / Corresponding author), Lindsey A. Allan, Agnieszka Skowyra

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Abstract

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

Original languageEnglish
Article numbere1516450
Pages (from-to)1-4
Number of pages4
JournalMolecular and Cellular Oncology
Volume5
Issue number6
Early online date11 Oct 2018
DOIs
Publication statusPublished - 2 Nov 2018

Keywords

  • apoptosis
  • Mcl-1
  • mitosis
  • mitotic cell death
  • proteolysis

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