Timed degradation of Mcl-1 controls mitotic cell death

Paul R. Clarke; Lindsey A. Allan; Agnieszka Skowyra

doi:10.1080/23723556.2018.1516450

Timed degradation of Mcl-1 controls mitotic cell death

Paul R. Clarke (Lead / Corresponding author), Lindsey A. Allan, Agnieszka Skowyra

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Abstract

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

Original language	English
Article number	e1516450
Pages (from-to)	1-4
Number of pages	4
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	6
Early online date	11 Oct 2018
DOIs	https://doi.org/10.1080/23723556.2018.1516450
Publication status	Published - 2 Nov 2018

Keywords

apoptosis
Mcl-1
mitosis
mitotic cell death
proteolysis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2018.1516450Licence: CC BY-NC-ND

Final Published VersionFinal published version, 2.05 MBLicence: CC BY-NC-ND

Cite this

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abstract = "Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.",

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AB - Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

KW - apoptosis

KW - Mcl-1

KW - mitosis

KW - mitotic cell death

KW - proteolysis

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Timed degradation of Mcl-1 controls mitotic cell death

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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