Abstract
Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.
| Original language | English |
|---|---|
| Article number | e1516450 |
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Molecular and Cellular Oncology |
| Volume | 5 |
| Issue number | 6 |
| Early online date | 11 Oct 2018 |
| DOIs | |
| Publication status | Published - 2 Nov 2018 |
Keywords
- apoptosis
- Mcl-1
- mitosis
- mitotic cell death
- proteolysis
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Cite this
Clarke, P. R., Allan, L. A., & Skowyra, A. (2018). Timed degradation of Mcl-1 controls mitotic cell death. Molecular and Cellular Oncology, 5(6), 1-4. [e1516450]. https://doi.org/10.1080/23723556.2018.1516450