Abstract
Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.
| Original language | English |
|---|---|
| Article number | e1516450 |
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Molecular and Cellular Oncology |
| Volume | 5 |
| Issue number | 6 |
| Early online date | 11 Oct 2018 |
| DOIs | |
| Publication status | Published - 2 Nov 2018 |
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Keywords
- apoptosis
- Mcl-1
- mitosis
- mitotic cell death
- proteolysis
Cite this
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Timed degradation of Mcl-1 controls mitotic cell death. / Clarke, Paul R. (Lead / Corresponding author); Allan, Lindsey A.; Skowyra, Agnieszka.
In: Molecular and Cellular Oncology, Vol. 5, No. 6, e1516450, 02.11.2018, p. 1-4.Research output: Contribution to journal › Article
TY - JOUR
T1 - Timed degradation of Mcl-1 controls mitotic cell death
AU - Clarke, Paul R.
AU - Allan, Lindsey A.
AU - Skowyra, Agnieszka
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.
AB - Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.
KW - apoptosis
KW - Mcl-1
KW - mitosis
KW - mitotic cell death
KW - proteolysis
UR - http://www.scopus.com/inward/record.url?scp=85054868971&partnerID=8YFLogxK
U2 - 10.1080/23723556.2018.1516450
DO - 10.1080/23723556.2018.1516450
M3 - Article
C2 - 30525093
AN - SCOPUS:85054868971
VL - 5
SP - 1
EP - 4
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 6
M1 - e1516450
ER -