Timed degradation of Mcl-1 controls mitotic cell death

Paul R. Clarke (Lead / Corresponding author), Lindsey A. Allan, Agnieszka Skowyra

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)
    185 Downloads (Pure)

    Abstract

    Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

    Original languageEnglish
    Article numbere1516450
    Pages (from-to)1-4
    Number of pages4
    JournalMolecular and Cellular Oncology
    Volume5
    Issue number6
    Early online date11 Oct 2018
    DOIs
    Publication statusPublished - 2 Nov 2018

    Keywords

    • apoptosis
    • Mcl-1
    • mitosis
    • mitotic cell death
    • proteolysis

    ASJC Scopus subject areas

    • Molecular Medicine
    • Cancer Research

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