Abstract
Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.
Original language | English |
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Article number | e1516450 |
Pages (from-to) | 1-4 |
Number of pages | 4 |
Journal | Molecular and Cellular Oncology |
Volume | 5 |
Issue number | 6 |
Early online date | 11 Oct 2018 |
DOIs | |
Publication status | Published - 2 Nov 2018 |
Keywords
- apoptosis
- Mcl-1
- mitosis
- mitotic cell death
- proteolysis
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research