Timed degradation of Mcl-1 controls mitotic cell death

Paul R. Clarke; Lindsey A. Allan; Agnieszka Skowyra

doi:10.1080/23723556.2018.1516450

Timed degradation of Mcl-1 controls mitotic cell death

Paul R. Clarke (Lead / Corresponding author)
, Lindsey A. Allan
, Agnieszka Skowyra

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

258 Downloads (Pure)

Abstract

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

Original language	English
Article number	e1516450
Pages (from-to)	1-4
Number of pages	4
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	6
Early online date	11 Oct 2018
DOIs	https://doi.org/10.1080/23723556.2018.1516450
Publication status	Published - 2 Nov 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

apoptosis
Mcl-1
mitosis
mitotic cell death
proteolysis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2018.1516450Licence: CC BY-NC-ND

Final Published VersionFinal published version, 2.05 MBLicence: CC BY-NC-ND

Cite this

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title = "Timed degradation of Mcl-1 controls mitotic cell death",

abstract = "Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.",

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author = "Clarke, \{Paul R.\} and Allan, \{Lindsey A.\} and Agnieszka Skowyra",

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T1 - Timed degradation of Mcl-1 controls mitotic cell death

AU - Clarke, Paul R.

AU - Allan, Lindsey A.

AU - Skowyra, Agnieszka

PY - 2018/11/2

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N2 - Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

AB - Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

KW - apoptosis

KW - Mcl-1

KW - mitosis

KW - mitotic cell death

KW - proteolysis

UR - https://www.scopus.com/pages/publications/85054868971

U2 - 10.1080/23723556.2018.1516450

DO - 10.1080/23723556.2018.1516450

M3 - Article

C2 - 30525093

AN - SCOPUS:85054868971

SN - 2372-3556

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JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 6

M1 - e1516450

ER -

Timed degradation of Mcl-1 controls mitotic cell death

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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