Tissue glue: a potential role in the management of intraoperative oesophageal perforation

Sushil Rodrigues Ranjan, Samit Majumdar, Jaiganesh Manickavasagam (Lead / Corresponding author), Susanne Flach

Research output: Contribution to journalArticlepeer-review


An 85-year-old man suffering from oropharyngeal dysphagia due to a pharyngeal pouch and cricopharyngeal spasm underwent endoscopic stapling of the pouch under general anaesthesia. During the procedure, an iatrogenic perforation of the oesophagus was noticed. After considering several options, 5 mL of Tisseel tissue glue was used to seal the perforation intraoperatively. The patient was started on intravenous co-amoxiclav, kept nil by mouth and fed via a nasogastric tube. After 4 days of observation mediastinal collection and any leakage was ruled out with a gastrografin contrast swallow procedure. At this point he was considered safe for oral intake.

Original languageEnglish
Article numbere232568
Number of pages4
JournalBMJ Case Reports
Issue number7
Early online date31 Jul 2020
Publication statusPublished - Jul 2020


  • cancer intervention
  • ear, nose and throat/otolaryngology
  • gastroenterology
  • oesophagus

ASJC Scopus subject areas

  • General Medicine


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