Tissue surface as the reference arm in Fourier domain optical coherence tomography

Nikola Krstajić, Christian Tom A. Brown, Kishan Dholakia, Mario Ettore Giardini

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    We present a simple method applicable to common-path Fourier domain optical coherence tomography (OCT) in which the tissue surface is used as the reference arm. We propose using aluminium hydroxide powder as a potential tissue surface diffuser to allow wider application of this method. This technique allows one to avoid placing a reference arm reflective element, such as glass plate, on tissue, and intrinsically avoids both coherent and complex conjugate mirror artifacts associated with glass plates. Aluminium hydroxide can be sprayed onto tissue using spray nozzles commonly found in endoscopes. The sensitivity of the tissue reference arm common-path OCT image is 94 dB for a 50-μs charge-coupled device integration time, and 97.5 dB for a 200-μs CCD integration time.

    Original languageEnglish
    Article number071305
    JournalJournal of Biomedical Optics
    Issue number7
    Publication statusPublished - Jul 2012


    • Common-path interferometry
    • Optical coherence tomography

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Atomic and Molecular Physics, and Optics
    • Biomaterials
    • Biomedical Engineering


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