TLR signalling regulated antigen presentation in dendritic cells

Colin Watts; Michele A. West; Rossana Zaru

doi:10.1016/j.coi.2009.12.005

TLR signalling regulated antigen presentation in dendritic cells

Colin Watts, Michele A. West, Rossana Zaru

Research output: Contribution to journal › Review article › peer-review

147 Citations (Scopus)

Abstract

Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, P13-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.

Original language	English
Pages (from-to)	124-130
Number of pages	7
Journal	Current Opinion in Immunology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.coi.2009.12.005
Publication status	Published - Feb 2010

Keywords

MHC CLASS-II
TOLL-LIKE RECEPTORS
CROSS-PRESENTATION
DISTINCT PATHWAYS
DOWN-REGULATION
IN-VIVO
ACTIVATION
MATURATION
AUTOPHAGY
EXPRESSION

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10.1016/j.coi.2009.12.005

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title = "TLR signalling regulated antigen presentation in dendritic cells",

abstract = "Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, P13-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.",

keywords = "MHC CLASS-II, TOLL-LIKE RECEPTORS, CROSS-PRESENTATION, DISTINCT PATHWAYS, DOWN-REGULATION, IN-VIVO, ACTIVATION, MATURATION, AUTOPHAGY, EXPRESSION",

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AU - Watts, Colin

AU - West, Michele A.

AU - Zaru, Rossana

PY - 2010/2

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N2 - Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, P13-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.

AB - Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, P13-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.

KW - MHC CLASS-II

KW - TOLL-LIKE RECEPTORS

KW - CROSS-PRESENTATION

KW - DISTINCT PATHWAYS

KW - DOWN-REGULATION

KW - IN-VIVO

KW - ACTIVATION

KW - MATURATION

KW - AUTOPHAGY

KW - EXPRESSION

U2 - 10.1016/j.coi.2009.12.005

DO - 10.1016/j.coi.2009.12.005

M3 - Review article

C2 - 20083398

SN - 0952-7915

VL - 22

SP - 124

EP - 130

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 1

ER -

TLR signalling regulated antigen presentation in dendritic cells

Abstract

Keywords

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