TLR signalling regulated antigen presentation in dendritic cells

Colin Watts, Michele A. West, Rossana Zaru

    Research output: Contribution to journalReview article

    110 Citations (Scopus)

    Abstract

    Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, P13-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.

    Original languageEnglish
    Pages (from-to)124-130
    Number of pages7
    JournalCurrent Opinion in Immunology
    Volume22
    Issue number1
    DOIs
    Publication statusPublished - Feb 2010

    Keywords

    • MHC CLASS-II
    • TOLL-LIKE RECEPTORS
    • CROSS-PRESENTATION
    • DISTINCT PATHWAYS
    • DOWN-REGULATION
    • IN-VIVO
    • ACTIVATION
    • MATURATION
    • AUTOPHAGY
    • EXPRESSION

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