Tolerability of spironolactone in patients with chronic heart failure: a cautionary message

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Aim
    To assess how well heart failure patients tolerate spironolactone in routine clinical practice.
    Design
    Retrospective analysis of 226 patients attending a specialist heart failure clinic.
    Results
    One hundred and thirty of 226 (57.5%) patients tried spironolactone at least once. Forty-four of 130 (33.8%) discontinued spironolactone due to side-effects after a mean of 11.1 months; 59/141 (41.8%) trials of spironolactone resulted in at least one side-effect; therapy was stopped in 30/141 (21.3%) trials due to raised potassium or creatinine. Significant risk factors for raised potassium/creatinine were age and baseline potassium level.
    Conclusions
    Potentially serious side-effects are common despite appropriate use of spironolactone.


    Original languageEnglish
    Pages (from-to)554-557
    Number of pages4
    JournalBritish Journal of Clinical Pharmacology
    Volume58
    Issue number5
    Early online date27 Jul 2004
    DOIs
    Publication statusPublished - Nov 2004

    Keywords

    • Aged
    • Congestive
    • Heart failure
    • Spironolactone

    Fingerprint

    Dive into the research topics of 'Tolerability of spironolactone in patients with chronic heart failure: a cautionary message'. Together they form a unique fingerprint.

    Cite this