Abstract
The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.
Original language | English |
---|---|
Pages (from-to) | 561-564 |
Number of pages | 4 |
Journal | Journal of Investigative Dermatology |
Volume | 136 |
Issue number | 3 |
Early online date | 19 Feb 2016 |
DOIs |
|
Publication status | Published - Mar 2016 |
Keywords
- Cytokines
- Dermatitis, Atopic
- Humans
- Intermediate filament proteins
- Tight junction proteins
- beta-defensins
- Comment
- Journal article