Too much, too little or just enough: a Goldilocks effect for IL-13 and skin barrier regulation?

Jessica Strid (Lead / Corresponding author), W. H. Irwin McLean, Alan D. Irvine (Lead / Corresponding author)

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Abstract

The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

Original languageEnglish
Pages (from-to)561-564
Number of pages4
JournalJournal of Investigative Dermatology
Volume136
Issue number3
Early online date19 Feb 2016
DOIs
Publication statusPublished - Mar 2016

Keywords

  • Cytokines
  • Dermatitis, Atopic
  • Humans
  • Intermediate filament proteins
  • Tight junction proteins
  • beta-defensins
  • Comment
  • Journal article

Fingerprint Dive into the research topics of 'Too much, too little or just enough: a Goldilocks effect for IL-13 and skin barrier regulation?'. Together they form a unique fingerprint.

  • Cite this