Too much, too little or just enough: a Goldilocks effect for IL-13 and skin barrier regulation?

TY - JOUR

T1 - Too much, too little or just enough

T2 - a Goldilocks effect for IL-13 and skin barrier regulation?

AU - Strid, Jessica

AU - McLean, W. H. Irwin

AU - Irvine, Alan D.

N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016/3

Y1 - 2016/3

N2 - The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

AB - The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

KW - Cytokines

KW - Dermatitis, Atopic

KW - Humans

KW - Intermediate filament proteins

KW - Tight junction proteins

KW - beta-defensins

KW - Comment

KW - Journal article

U2 - 10.1016/j.jid.2015.12.025

DO - 10.1016/j.jid.2015.12.025

M3 - Comment/debate

C2 - 26902126

SN - 0022-202X

VL - 136

SP - 561

EP - 564

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 3

ER -