Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

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• Finished

  A Platform for Drug Target Deconvolution and Exploitation

  Gilbert, I. (Investigator), Horn, D. (Investigator), Pawlowic, M. C. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)

  31/12/20 → 30/05/25

  Project: Research

  • Chagas Disease 100%
  • LysR Family 74%
  • Visceral Leishmaniasis 66%
  • Leishmania Donovani 64%
  • Drug Discovery 62%

• Structure-Guided Drug Discovery for Malaria and Tuberculosis (joint with Structural Genomics Consortium)

  Gilbert, I. (Investigator), Gray, D. (Investigator), Read, K. (Investigator) & Wyatt, P. (Investigator)

  Bill and Melinda Gates Foundation

  1/01/19 → 6/07/24

  Project: Research

  • Transfer RNA 100%
  • Plasmodium Falciparum 80%
  • Pullout 60%
  • Lysine Transfer RNA Ligase 60%
  • LysR Family 53%

• Wellcome Centre for Anti-Infectives Research

  Baragana, B. (Investigator), Cook, S. (Investigator), De Rycker, M. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator), Lee, M. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)

  1/04/17 → 1/04/25

  Project: Research

  • Drug Discovery 100%
  • Trypanosoma Cruzi (T. cruzi) 82%
  • Chagas Disease 73%
  • Trypanosoma Cruzi 66%
  • Visceral Leishmaniasis 53%