Topical 5-aminolaevulinic acid photodynamic therapy for the treatment of skin conditions other than non-melanoma skin cancer

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    Abstract

    Topical 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) is used increasingly for superficial non-melanoma skin cancer (NMSC) and dysplasia. However, the relative accumulation of the photosensitizer protoporphyrin IX (PpIX) in diseased tissue is not specific for neoplastic disease, and has been shown after the application of ALA to benign proliferative skin conditions such as viral warts and psoriasis. This review appraises the quality of evidence available for the use of topical ALA-PDT in the treatment of skin conditions other than NMSC. The diseases that have been studied in most detail are recalcitrant viral warts, acne, psoriasis and cutaneous T-cell lymphoma. Publications relating to the treatment of other diseases by topical PDT are restricted to small case series or case reports. The relevant literature will be discussed and the potential for topical PDT in the treatment of several skin diseases is highlighted, although more detailed studies are required to clarify the role of PDT beyond the treatment of NMSC.
    Original languageEnglish
    Pages (from-to)178-188
    Number of pages11
    JournalThe British journal of dermatology
    Volume146
    Issue number2
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Photosensitizing Agents
    • Warts
    • Skin Diseases
    • Psoriasis
    • Lymphoma, T-Cell
    • Humans
    • Photochemotherapy
    • Skin Neoplasms
    • Acne Vulgaris
    • Aminolevulinic Acid

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