Abstract
This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (I session), and 58 with 105 lesions received cryotherapy (2 freeze-thaw cycles). Patients with an incomplete response at 3 months received 2 further MAL PDT sessions (n = 20) or repeat cryotherapy (n = 16). 100 lesions treated with MAL PDT and 93 lesions treated with cryotherapy were in complete response at 3 months after the last treatment and evaluable for recurrence over 5 years. There was no difference in 5-year recurrence rates with either treatment (20% with cryotherapy vs. 22% with MAL PDT, p = 0.86). However, more patients had an excellent cosmetic outcome with MAL PDT (60% vs. 16% with cryotherapy, p = 0.00078). These results provide support for the use of MAL PDT as a non-invasive, selective treatment alternative for primary superficial basal cell carcinoma.
Original language | English |
---|---|
Pages (from-to) | 547-553 |
Number of pages | 7 |
Journal | European Journal of Dermatology |
Volume | 18 |
Issue number | 5 |
Publication status | Published - 2008 |
Keywords
- methyl aminolaevulinate
- photodynamic therapy
- superficial basal cell carcinoma
- FOLLOW-UP
- GUIDELINES
- CANCER
- AGE
- CRYOSURGERY
- MANAGEMENT
- RECURRENCE
- SKIN